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Adolescent Testicular Sperm Retrieval

  • I-Shen Huang
  • Robert E. Brannigan
  • Barbara A. LockartEmail author
Chapter

Abstract

A 16-year-old male presented to a community hospital with 2 weeks of decreased urinary flow, which ultimately progressed to urinary retention. An indwelling Foley catheter was placed, and initial evaluation revealed no laboratory abnormalities. Magnetic resonance imaging (MRI) of the abdomen and pelvis demonstrated an enhancing mass within the anterior prostate measuring 4.2 × 5.2 × 4.6 cm. A right femoral head lesion was also noted. Percutaneous biopsy of the prostatic lesion confirmed a diagnosis of embryonal rhabdomyosarcoma, and further staging evaluation revealed Stage 4, high-risk disease. The patient was transferred to a tertiary-care pediatric hospital for treatment with the following chemotherapeutic regimen: vincristine, irinotecan, ifosfamide, etoposide, doxorubicin, cyclophosphamide, dactinomycin, and human IgG1 monoclonal antibody. The total cyclophosphamide equivalent dose (CED) for the planned treatment regimen was 16,290 mg/m2.

Keywords

Oncofertility Adolescence Sperm retrieval Embryonal rhabdomyosarcoma Microdissection testicular sperm extraction (microTESE) 

References

  1. 1.
    Schover LR, Brey K, Lichtin A, Lipshultz LI, Jeha S. Knowledge and experience regarding cancer, infertility, and sperm banking in younger male survivors. J Clin Oncol. 2002;20(7):1880–9.CrossRefPubMedCentralGoogle Scholar
  2. 2.
    Schover LR, Brey K, Lichtin A, Lipshultz LI, Jeha S. Oncologists’ attitudes and practices regarding banking sperm before cancer treatment. J Clin Oncol. 2002;20(7):1890–7.CrossRefPubMedCentralGoogle Scholar
  3. 3.
    Oktay K, Harvey BE, Partridge AH, Quinn GP, Reinecke J, Taylor HS, et al. Fertility preservation in patients with cancer: ASCO clinical practice guideline update. J Clin Oncol. 2018;36(19):1994–2001.CrossRefPubMedCentralGoogle Scholar
  4. 4.
    van Casteren NJ, Dohle GR, Romijn JC, de Muinck Keizer-Schrama SMPF, Weber RFA, van den Heuvel-Eibrink MM. Semen cryopreservation in pubertal boys before gonadotoxic treatment and the role of endocrinologic evaluation in predicting sperm yield. Fertil Steril. 2008;90(4):1119–25.CrossRefPubMedCentralGoogle Scholar
  5. 5.
    Nielsen CT, Skakkebaek NE, Richardson DW, Darling JA, Hunter WM, Jørgensen M, et al. Onset of the release of spermatozoa (spermarche) in boys in relation to age, testicular growth, pubic hair, and height. J Clin Endocrinol Metab. 1986;62(3):532–5.CrossRefPubMedCentralGoogle Scholar
  6. 6.
    Schmiegelow ML, Sommer P, Carlsen E, Sønksen JO, Schmiegelow K, Müller JR. Penile vibratory stimulation and electroejaculation before anticancer therapy in two pubertal boys. J Pediatr Hematol Oncol. 1998;20(5):429–30.CrossRefPubMedCentralGoogle Scholar
  7. 7.
    Meng X, Fan L, Wang T, Wang S, Wang Z, Liu J. Electroejaculation combined with assisted reproductive technology in psychogenic anejaculation patients refractory to penile vibratory stimulation. Transl Androl Urol. 2018;7(Suppl 1):S17–22.CrossRefPubMedCentralGoogle Scholar
  8. 8.
    Gat I, Toren A, Hourvitz A, Raviv G, Band G, Baum M, et al. Sperm preservation by electroejaculation in adolescent cancer patients. Pediatr Blood Cancer. 2014;61(2):286–90.CrossRefPubMedCentralGoogle Scholar
  9. 9.
    Adank MC, van Dorp W, Smit M, van Casteren NJ, Laven JSE, Pieters R, et al. Electroejaculation as a method of fertility preservation in boys diagnosed with cancer: a single-center experience and review of the literature. Fertil Steril. 2014;102(1):199–205.e1.CrossRefPubMedCentralGoogle Scholar
  10. 10.
    Berookhim BM, Mulhall JP. Outcomes of operative sperm retrieval strategies for fertility preservation among males scheduled to undergo cancer treatment. Fertil Steril. 2014;101(3):805–11.CrossRefPubMedCentralGoogle Scholar
  11. 11.
    Deruyver Y, Vanderschueren D, Van der Aa F. Outcome of microdissection TESE compared with conventional TESE in non-obstructive azoospermia: a systematic review. Andrology. 2014;2(1):20–4.CrossRefPubMedCentralGoogle Scholar
  12. 12.
    Smart E, Lopes F, Rice S, Nagy B, Anderson RA, Mitchell RT, et al. Chemotherapy drugs cyclophosphamide, cisplatin and doxorubicin induce germ cell loss in an in vitro model of the prepubertal testis. Sci Rep. 2018;8(1):1773.CrossRefPubMedCentralGoogle Scholar
  13. 13.
    Green DM, Liu W, Kutteh WH, Ke RW, Shelton KC, Sklar CA, et al. Cumulative alkylating agent exposure and semen parameters in adult survivors of childhood cancer: a report from the St Jude Lifetime Cohort Study. Lancet Oncol. 2014;15(11):1215–23.CrossRefPubMedCentralGoogle Scholar
  14. 14.
    Grewenig A, Schuler N, Rübe CE. Persistent DNA damage in spermatogonial stem cells after fractionated low-dose irradiation of testicular tissue. Int J Radiat Oncol Biol Phys. 2015;92(5):1123–31.CrossRefPubMedCentralGoogle Scholar
  15. 15.
    Carlsen E, Andersson A-M, Petersen JH, Skakkebaek NE. History of febrile illness and variation in semen quality. Hum Reprod. 2003;18(10):2089–92.CrossRefPubMedCentralGoogle Scholar
  16. 16.
    Trottmann M, Becker AJ, Stadler T, Straub J, Soljanik I, Schlenker B, et al. Semen quality in men with malignant diseases before and after therapy and the role of cryopreservation. Eur Urol. 2007;52(2):355–67.CrossRefPubMedCentralGoogle Scholar
  17. 17.
    Schlegel PN. Testicular sperm extraction: microdissection improves sperm yield with minimal tissue excision. Hum Reprod. 1999;14(1):131–5.CrossRefPubMedCentralGoogle Scholar
  18. 18.
    Hsiao W, Stahl PJ, Osterberg EC, Nejat E, Palermo GD, Rosenwaks Z, et al. Successful treatment of postchemotherapy azoospermia with microsurgical testicular sperm extraction: the Weill Cornell experience. J Clin Oncol. 2011;29(12):1607–11.CrossRefPubMedCentralGoogle Scholar
  19. 19.
    Byrne J, Rasmussen SA, Steinhorn SC, Connelly RR, Myers MH, Lynch CF, et al. Genetic disease in offspring of long-term survivors of childhood and adolescent cancer. Am J Hum Genet. 1998;62(1):45–52.CrossRefPubMedCentralGoogle Scholar
  20. 20.
    Depalo R, Falagario D, Masciandaro P, Nardelli C, Vacca MP, Capuano P, et al. Fertility preservation in males with cancer: 16-year monocentric experience of sperm banking and post-thaw reproductive outcomes. Ther Adv Med Oncol. 2016;8(6):412–20.CrossRefPubMedCentralGoogle Scholar
  21. 21.
    Chiba K, Tanaka M, Ishida T, Sumii K, Fukuda T, Okada K, et al. Mp07-18 the usage rate of semen cryopreservation before cancer treatment. J Urol. 2018;199(4):e94–5.Google Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • I-Shen Huang
    • 1
    • 2
  • Robert E. Brannigan
    • 3
  • Barbara A. Lockart
    • 4
    Email author
  1. 1.Department of UrologySchool of Medicine, National Yang-Ming UniversityTaipeiTaiwan
  2. 2.Department of UrologyTaipei Veterans General HospitalTaipeiTaiwan
  3. 3.Division of Male Reproductive Surgery and Men’s Health, Department of UrologyNorthwestern University Feinberg School of MedicineChicagoUSA
  4. 4.Solid Tumors and Fertility PreservationAnn & Robert H. Lurie Children’s Hospital of ChicagoChicagoUSA

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