Fertility Preservation in an Adolescent with an Ovotesticular Disorder of Sexual Development

  • Teresa Almeida-SantosEmail author
  • R. Cardoso
  • A. Carvalho
  • Ana Paula Sousa


A 12-year-old boy was referred to pediatric surgery for correction of right unilateral cryptorchidism. The surgeon suspected the presence of testicular and ovarian tissue in the right gonad, and so the child was further referred to a pediatric endocrinologist to investigate a disorder of sexual development (DSD). A biopsy was performed that revealed numerous primordial follicles and some primary and secondary follicles, surrounded by ovarian stroma and testicular parenchyma, with seminiferous tubules displaying Sertoli and germinal cells. Focal spermatogenesis was present as well as testicular stroma with focal Leydig cells. The patient had a male phenotype with a small penis with a slight ventral curve and a palpable, homogeneous, approximately 2 cc gonad in the left scrotum. The patient had been referred to another department in early childhood for correction of urogenital abnormalities, but no investigation or intervention was undertaken at that time.


Fertility preservation Cryptorchidism Gonad Urogenital abnormalities Testosterone therapy 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Teresa Almeida-Santos
    • 1
    • 2
    • 3
    • 4
    Email author
  • R. Cardoso
    • 5
  • A. Carvalho
    • 1
    • 3
  • Ana Paula Sousa
    • 1
    • 3
  1. 1.Center for Fertility Preservation, Reproductive Medicine UnitCentro Hospitalar e Universitário de CoimbraCoimbraPortugal
  2. 2.Faculty of MedicineUniversity of CoimbraCoimbraPortugal
  3. 3.Center for Neuroscience and Cell BiologyUniversity of CoimbraCoimbraPortugal
  4. 4.Human Reproduction DepartmentCoimbra University HospitalCoimbraPortugal
  5. 5.Pediatric Endocrinology Unit, Hospital PediátricoCentro Hospitalar e Universitário de CoimbraCoimbraPortugal

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