Stress and Somatic Symptoms pp 3-16 | Cite as
Stress, Vulnerability, and Resilience
Abstract
Causes of stress are classified into psychosocial factors and environmental (bioecological) factors. Vulnerability refers to poorly adapting to stressors and showing inappropriate responses that can become persistent states of stress. In contrast, resilience is linked to being able to perceive stressful events in less threatening ways, promoting adaptive coping strategies. Differences in individual vulnerability and resilience occur across sex, age, and culture. The underlying mechanisms of vulnerability and resilience are known to depend on a combination of genetic and nongenetic factors. Psychosocial factors, behavioral factors, neuroendocrine stress responses, genetic and epigenetic mechanisms, and neural circuitry are likely to be involved in vulnerability and resilience to stress. In particular, the functional capacity of the brain structures involved in the integrated circuits that mediate mood and emotion determines stress resilience.
Keywords
Stress Vulnerability Psychosocial factors Behavioral factors Neuroendocrine stress responses Genetic mechanisms Epigenetic mechanisms Neural circuitryReferences
- 1.Greenberg JS. Coping with stress: a practical guide. Dubuque: Wm C Publishers; 1990.Google Scholar
- 2.Selye H. The stress of life. New York: McGraw-Hill; 1956.Google Scholar
- 3.Derogatis LR, Coons HL. Self-report measures of stress. In: Goldberg L, Breznitz S, editors. Handbook of stress – theoretical and clinical aspects. 2nd ed. New York: The Free Press; 1993.Google Scholar
- 4.Lipowski ZJ. Psychosomatic medicine and liaison psychiatry. New York: Plenum Medical Book Co; 1985.Google Scholar
- 5.Lazarus RS. Patterns of adjustment. New York: McGraw-Hill; 1976.Google Scholar
- 6.Lazarus RS. The stress and coping paradigm. Edisdorfer C, Cohen D, Kleinman A, et al.. Models for clinical psychopathology. New York; Spectrum; 1981Google Scholar
- 7.Reiser MF. Psychophysiology of stress and its sequelae. In: Reiser MF, editor. Mind, brain, body: toward a convergence of psychoanalysis and neurobiology. New York: Basic Books; 1984.Google Scholar
- 8.Selye H. Stress without distress. New York: J.B. Lippincott; 1974.Google Scholar
- 9.Rice PL. Stress and health: principles and practice for coping and wellness. Pacific Grove: Brooks/Cole Publishing Co; 1987.Google Scholar
- 10.Girdano DA, Everly G. Controlling stress and tension: a holistic approach. New Jersey: Prentice-Hall; 1979.Google Scholar
- 11.Del Giudice M, Ellis BJ, Shirtcliff EA. The adaptive calibration model of stress responsivity. Neurosci Biobehav Rev. 2011;35:1562–92.PubMedGoogle Scholar
- 12.Rutter M. Implications of resilience concepts for scientific understanding. Ann N Y Acad Sci. 2006;1094:1–12.PubMedGoogle Scholar
- 13.Franklin TB, Saab BJ, Mansuy IM. Neural mechanisms of stress resilience and vulnerability. Neuron. 2012;75:747–61.PubMedGoogle Scholar
- 14.Masten AS. Ordinary magic. Resilience processes in development. Am Psychol. 2001;56:227–38.PubMedGoogle Scholar
- 15.Masten AS, Coatsworth JD. The development of competence in favorable and unfavorable environments. Lessons from research on successful children. Am Psychol. 1998;53:205–20.PubMedGoogle Scholar
- 16.Rutter M. Resilience in the face of adversity. Protective factors and resistance to psychiatric disorder. Br J Psychiatry. 1985;147:598–611.PubMedGoogle Scholar
- 17.Yam KY, Naninck EF, Schmidt MV, et al. Early-life adversity programs emotional functions and the neuroendocrine stress system: the contribution of nutrition, metabolic hormones and epigenetic mechanisms. Stress. 2015;18:328–42.Google Scholar
- 18.Santarelli S, Zimmermann C, Kalideris G, et al. An adverse early life environment can enhance stress resilience in adulthood. Psychoneuroendocrinology. 2017;78:213–21.PubMedGoogle Scholar
- 19.Oomen CA, Soeters H, Audureau N, et al. Severe early life stress hampers spatial learning and neurogenesis, but improves hippocampal synaptic plasticity and emotional learning under high-stress conditions in adulthood. J Neurosci. 2010;30:6635–45.PubMedGoogle Scholar
- 20.Southwick SM, Vythilingam M, Charney DS. The psychobiology of depression and resilience to stress: implications for prevention and treatment. Annu Rev Clin Psychol. 2005;1:255–91.PubMedGoogle Scholar
- 21.Sherrer MV. The role of cognitive appraisal in adaptation to traumatic stress in adults with serious mental illness: a critical review. Trauma Violence Abuse. 2011;12:151–67.PubMedGoogle Scholar
- 22.Antonovsky A. Health, stress and coping. San Francisco: Jossey-Bass; 1982.Google Scholar
- 23.Cotton DHG. Stress management: an integrated approach to therapy. New York: Brunner/Mazel; 1990. p. 80–110.Google Scholar
- 24.Ong AD, Bergeman CS, Bisconti TL, et al. Psychological resilience, positive emotions, and successful adaptation to stress in later life. J Pers Soc Psychol. 2006;91:730–49.PubMedGoogle Scholar
- 25.Tugade MM, Fredrickson BL. Resilient individuals use positive emotions to bounce back from negative emotional experiences. J Pers Soc Psychol. 2004;86:320–33.PubMedPubMedCentralGoogle Scholar
- 26.Fredrickson BL. The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions. Am Psychol. 2001;56:218–26.PubMedPubMedCentralGoogle Scholar
- 27.Alim TN, Feder A, Graves RE, et al. Trauma, resilience, and recovery in a high-risk African-American population. Am J Psychiatry. 2008;165:1566–75.PubMedGoogle Scholar
- 28.Ryff CD, Keyes CL. The structure of psychological well-being revisited. J Pers Soc Psychol. 1995;69:719–27.PubMedGoogle Scholar
- 29.Pargement KI, Koenig BW, Perez L. Patterns of positive and negative religious coping with major life stressors. J Sci Study Relig. 1998;37:710–24.Google Scholar
- 30.Feder A, Nestler EJ, Charney DS. Psychobiology and molecular genetics of resilience. Nat Rev/Neurosci. 2009;10:446–57.Google Scholar
- 31.Heim C, Nemeroff CB. The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies. Biol Psychiatry. 2001;49:1023–39.PubMedGoogle Scholar
- 32.Karlamangla AS, Singer BH, McEwen BS, et al. Allostatic load as a predictor of functional decline. MacArthur studies of successful aging. J Clin Epidemiol. 2002;55:696–710.PubMedGoogle Scholar
- 33.McEwen BS, Milner TA. Hippocampal formation: shedding light on the influence of sex and stress on the brain. Brain Res Rev. 2007;55:343–55.PubMedPubMedCentralGoogle Scholar
- 34.Brown ES, Woolston DJ, Frol AB. Amygdala volume in patients receiving chronic corticosteroid therapy. Biol Psychiatry. 2008;63:705–9.PubMedGoogle Scholar
- 35.de Kloet ER, Joels M, Holsboer F. Stress and the brain: from adaptation to disease. Nat Rev Neurosci. 2005;6:463–75.PubMedGoogle Scholar
- 36.Charney DS. Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress. Am J Psychiatry. 2004;161:195–216.PubMedGoogle Scholar
- 37.de Kloet ER, Deriik RH, Meijer OC. Therapy insight: is there an imbalanced response of mineralocorticoid and glucocorticoid receptors in depression? Nat Clin Pract Endocrinol Metab. 2007;3:168–79.PubMedGoogle Scholar
- 38.Charney DS. Neuroanatomical circuits modulating fear and anxiety behaviors. Acta Psychiatr Scand Suppl. 2003;417:38–50.Google Scholar
- 39.Sajdyk TJ, Shekhar A, Gehlert DR. Interactions between NPY and CRF in the amygdala to regulate emotionality. Neuropeptides. 2004;38:225–34.PubMedGoogle Scholar
- 40.Morgan CA, Wang S, Southwick SM, et al. Plasma neuropeptide Y concentrations in humans exposed to military survival training. Biol Psychiatry. 2000;47:902–9.PubMedGoogle Scholar
- 41.Fuller JL, Thompson WR. Foundations of behavior genetics. St. Louis: Mosby; 1978.Google Scholar
- 42.McIlwrick S, Rechenberg A, Matthes M, et al. Genetic predisposition for high stress reactivity amplifies effects of early-life adversity. Psychoneuroendocrinology. 2016;70:85–97.PubMedPubMedCentralGoogle Scholar
- 43.Bradley RG, Binder EB, Epstein MP, et al. Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene. Arch Gen Psychiatry. 2008;65:190–200.PubMedPubMedCentralGoogle Scholar
- 44.Caspi A, Sugden K, Moffitt TE, et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science. 2003;301:386–9.PubMedGoogle Scholar
- 45.Kendler KS, Kuhn JW, Vittum J, et al. The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication. Arch Gen Psychiatry. 2005;62:529–35.PubMedGoogle Scholar
- 46.Gillespie NA, Whitfield JB, Williams B, et al. The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression. Psychol Med. 2005;35:101–11.PubMedGoogle Scholar
- 47.Stein MB, Campbell-Sills L, Gelernter J. Genetic variation in 5-HTTLPR is associated with emotional resilience. Am J Med Genet B Neuropsychiatr Genet. 2009;150B:900–6.PubMedPubMedCentralGoogle Scholar
- 48.Heinz A, Smolka MN. The effects of catechol O-methyltransferase genotype on brain activation elicited by affective stimuli and cognitive tasks. Rev Neurosci. 2006;17:359–67.PubMedGoogle Scholar
- 49.Zhou Z, Zhu G, Hariri AR, et al. Genetic variation in human NPY expression affects stress response and emotion. Nature. 2008;452:997–1001.PubMedPubMedCentralGoogle Scholar
- 50.Jabbi M, Korf J, Kema IP, et al. Convergent genetic modulation of the endocrine stress response involves polymorphic variations of 5-HTT, COMT and MAOA. Mol Psychiatry. 2007;12:483–90.PubMedGoogle Scholar
- 51.Smolka MN, Buhler M, Schumann G, et al. Gene-gene effects on central processing of aversive stimuli. Mol Psychiatry. 2007;12:307–17.PubMedGoogle Scholar
- 52.Mandelli L, Serretti A, Marino E, et al. Interaction between serotonin transporter gene, catechol-O-methyltransferase gene and stressful life events in mood disorders. Int J Neuropsychopharmacol. 2007;10:437–47.PubMedGoogle Scholar
- 53.Kaufman J, Yang B-Z, Douglas-Palumberi H, et al. Social supports and serotonin transporter gene moderate depression in maltreated children. Proc Natl Acad Sci U S A. 2004;101:17316–21.PubMedPubMedCentralGoogle Scholar
- 54.Kim JM, Stewart R, Kim SW, et al. Interactions between life stressors and susceptibility genes (5-HTTLPR and BDNF) on depression in Korean elders. Biol Psychiatry. 2007;62:423–8.PubMedGoogle Scholar
- 55.Kaufman J, Yang B-Z, Douglas-Palumberi H, et al. Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children. Biol Psychiatry. 2006;59:673–80.PubMedGoogle Scholar
- 56.Franklin TB, Mansuy IM. The involvement of epigenetic defects in mental retardation. Neurobiol Learn Mem. 2011;96:61–7.PubMedGoogle Scholar
- 57.Kubota T, Miyake K, Hirasawa T. Epigenetic understanding of gene-environment interactions in psychiatric disorders: a new concept of clinical genetics. Clin Epigenetics. 2012;4:1.PubMedPubMedCentralGoogle Scholar
- 58.McEwen BS, Eiland L, Hunter RG, et al. Stress and anxiety: structural plasticity and epigenetic regulation as a consequence of stress. Neuropharmacology. 2012;62:3–12.PubMedGoogle Scholar
- 59.Leigh H. Genes, memes, culture, and psychosomatic medicine: an integrative model. In: Koh KB, editor. Somatization and psychosomatic symptoms. New York: Springer; 2013.Google Scholar
- 60.Krishnan V, Han M-H, Graham DL, et al. Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell. 2007;131:391–404.PubMedGoogle Scholar
- 61.Bandler R, Shipley MT. Columnar organization in the midbrain periaqueductal gray: modules for emotional expression? Trends Neurosci. 1994;17:379–89.PubMedGoogle Scholar
- 62.Berton O, Covington IIIHE, Ebner K, et al. Induction of FosB in the periaqueductal gray by stress promotes active coping responses. Neuron. 2007;55:289–300.PubMedGoogle Scholar
- 63.Dedovic K, Renwick R, Najmeh KM, et al. The Montreal imaging stress task: using functional imaging to investigate the effects of perceiving and processing psychosocial stress in the human brain. J Psychiatry Neurosci. 2005;30:319–25.PubMedPubMedCentralGoogle Scholar
- 64.Delgado MR, Olsson A, Phelps EA. Extending animal models of fear conditioning to humans. Biol Psychol. 2006;73:39–48.PubMedGoogle Scholar
- 65.Milad MR, Quinn BT, Pitman RK, et al. Thickness of ventromedial prefrontal cortex in humans is correlated with extinction memory. Proc Natl Acad Sci U S A. 2005;102:10706–11.PubMedPubMedCentralGoogle Scholar
- 66.Schiller D, Levy I, Niv Y, et al. From fear to safety and back: reversal of fear in the human brain. J Neurosci. 2008;28:11517–25.PubMedPubMedCentralGoogle Scholar
- 67.Pizzagalli DA, Holmes AJ, Dillon DJ, et al. Reduced caudate and nucleus accumbens response to rewards in unmedicated subjects with major depressive disorder. Am J Psychiatry. 2008;166:702–10.Google Scholar
- 68.Sailer U, Robinson S, Fischmeister F, et al. Altered reward processing in the nucleus accumbens and mesial prefrontal cortex of patients with posttraumatic stress disorder. Neuropsychologia. 2008;46:2836–44.PubMedGoogle Scholar
- 69.Drevets WC, Price JL, Furey ML. Brain structural and functional abnormalities in mood disorders: implication for neurocircuitry models of depression. Brain Struct Funct. 2008;213:93–118.PubMedPubMedCentralGoogle Scholar
- 70.Sharot T, Riccardi AM, Raio CM, et al. Neural mechanisms mediating optimism bias. Nature. 2007;450:102–5.PubMedGoogle Scholar
- 71.Ressler KJ, Mayberg HS. Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic. Nat Neurosci. 2007;10:1116–24.PubMedPubMedCentralGoogle Scholar
- 72.Goldin PR, McRae K, Ramel W, et al. The neural bases of emotion regulation: reappraisal and suppression of negative emotion. Biol Psychiatry. 2008;63:577–86.PubMedGoogle Scholar
- 73.Ochsner KN, Ray RD, Cooper JC, et al. For better or for worse: neural systems supporting the cognitive down- and up-regulation of negative emotion. NeuroImage. 2004;23:483–99.PubMedGoogle Scholar
- 74.New AS, Fan J, Murrough JW, et al. A functional magnetic resonance imaging study of deliberate emotion regulation in PTSD and resilience. Biol Psychiatry. 2009;66:656–64.PubMedGoogle Scholar
- 75.Iarocci G, Yager J, Elfers T. What gene-environment interactions can tell us about social competence in typical and atypical populations. Brain Cogn. 2007;65:112–7.PubMedGoogle Scholar
- 76.Storm EE, Tecott LH. Social circuits: peptidergic regulation of mammalian social behavior. Neuron. 2005;47:483–6.PubMedGoogle Scholar
- 77.Rizzolatti G, Craighero L. The mirror-neuron system. Annu Rev Neurosci. 2004;27:169–92.PubMedGoogle Scholar
- 78.Pfeifer JH, Iacoboni M, Mazziotta JC, et al. Mirroring others’ emotions relates to empathy and interpersonal competence in children. NeuroImage. 2008;39:2067–85.Google Scholar
- 79.Domes G, Heinrichs M, Michel A, et al. Oxytocin improves mind-reading in humans. Biol Psychiatry. 2007;61:731–3.PubMedGoogle Scholar
- 80.Skuse DH, Gallagher L. Dopaminergic neuropeptide interactions in the social brain. Trends Cogn Sci. 2009;13:27–35.PubMedGoogle Scholar
- 81.Rilling JK, Gutman DA, Zeh TR, et al. A neural basis for social cooperation. Neuron. 2002;35:395–405.PubMedGoogle Scholar
- 82.Coan JA, Schaefer HS, Davidson RJ. Lending a hand: social regulation of the neural response to threat. Psychol Sci. 2006;17:1032–9.PubMedGoogle Scholar