Impact of the Microenvironment on Tumour Budding in Colorectal Cancer

  • Laurent MC Georges
  • Laurine Verset
  • Inti Zlobec
  • Pieter Demetter
  • Olivier De WeverEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1110)


Tumour Budding (TB) is recognized as an adverse prognostic factor in colorectal cancer (CRC). TB is the detachment of isolated cancer cells or small clusters of such cells mainly at the invasion front. One question that arises is of the role of the tumour stroma regarding the permissiveness of the formation and progression of TB. In this review, we will examine potential factors affecting TB, in particular we will analyse the potential effect of inflammation, hypoxia, extracellular matrix and Cancer-Associated Fibroblasts (CAFs).


Budding Cancer-associated fibroblast Epithelial-mesenchymal transition Migration Tumor-environment 


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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Laurent MC Georges
    • 1
  • Laurine Verset
    • 1
  • Inti Zlobec
    • 2
  • Pieter Demetter
    • 1
  • Olivier De Wever
    • 3
    • 4
    Email author
  1. 1.Department of Pathology, Erasme University HospitalUniversité Libre de BruxellesBrusselsBelgium
  2. 2.Institute of PathologyUniversity of BernBernSwitzerland
  3. 3.Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer ResearchGhent UniversityGhentBelgium
  4. 4.Cancer Research Institute Ghent (CRIG)GhentBelgium

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