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Pericytes in Tissue Engineering

  • Betül Çelebi-Saltik
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1109)

Abstract

Pericytes have crucial roles in blood-brain barrier function, blood vessel function/stability, angiogenesis, endothelial cell proliferation/differentiation, wound healing, and hematopoietic stem cells maintenance. They can be isolated from fetal and adult tissues and have multipotential differentiation capacity as mesenchymal stem cells (MSCs). All of these properties make pericytes as preferred cells in the field of tissue engineering. Current developments have shown that tissue-engineered three-dimensional (3D) systems including multiple cell layers (or types) and a supporting biological matrix represent the in vivo environment better than those monolayers on plastic dishes. Tissue-engineered models are also more ethical and cheaper systems than animal models. This chapter describes the role of pericytes in tissue engineering for regenerative medicine.

Keywords

Pericytes Tissue engineering Mesenchymal stem cells Hematopoietic stem cells Niche Scaffold Bone tissue engineering Cartilage tissue engineering Dermal tissue engineering Vascular tissue engineering Cardiac tissue engineering Blood tissue engineering 

Notes

Conflict of Interest Statement

The author declares that she has no conflicts of interest concerning this work.

Ethical Approval

This article does not contain any studies with human participants or animals performed by the author.

Informed Consent

This article does not contain any studies with human participants or animals performed by the author.

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© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Department of Stem Cell SciencesHacettepe University Graduate School of Health SciencesAnkaraTurkey
  2. 2.Center for Stem Cell Research and DevelopmentHacettepe UniversityAnkaraTurkey

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