Case Study 6: Treatments for Alcohol Use Disorder

  • Collin M. ReiffEmail author


This case discusses Susan, a 20-year-old female college student with alcohol use disorder, and explores the practical considerations that should be taken into account when prescribing pharmacotherapy for alcohol use disorder in the adolescent and young adult patient population. It reviews the indications, mechanisms of action, dosing, and current evidence base for acamprosate, naltrexone, and disulfiram.


Pharmacotherapy Alcohol use disorder Adolescent Acamprosate Naltrexone Disulfiram 


  1. 1.
    Plosker GL. Acamprosate: a review of its use in alcohol dependence. Drugs. 2015;75(11):1255–68.CrossRefGoogle Scholar
  2. 2.
    Simkin DR, Grenoble S. Pharmacotherapies for adolescent substance use disorders. Child Adolesc Psychiatr Clin N Am. 2010;19(3):591–608. Scholar
  3. 3.
    Stahl SM, Grady MM, Muntner M. Stahl’s essential psychopharmacology: the prescriber's guide, vol. 1–2. 4th ed. New York: Cambridge University Press; 2014. p. 195–7.Google Scholar
  4. 4.
    Niederhofer H, Staffen W. RETRACTED ARTICLE: acamprosate and its efficacy in treating alcohol dependent adolescents. Eur Child Adolesc Psychiatry. 2003;12(3):144–8.CrossRefGoogle Scholar
  5. 5.
    Fishman MJ, Winstanley EL, Curran E, et al. Treatment of opioid dependence in adolescents and young adults with extended release naltrexone: preliminary case-series and feasibility. Addiction. 2010;105(9):1669–76.CrossRefGoogle Scholar
  6. 6.
    Lifrak PD, Alterman AI, O’Brien CP, et al. Naltrexone for alcoholic adolescents. Am J Psychiatry. 1997;154(3):439–41.PubMedGoogle Scholar
  7. 7.
    Deas D, May MP, Randall C, et al. Naltrexone treatment of adolescent alcoholics: an open-label pilot study. J Child Adolesc Psychopharmacol. 2005;15(5):723–8.CrossRefGoogle Scholar
  8. 8.
    Niederhofer H, Staffen W. Comparison of disulfiram and placebo in treatment of alcohol dependence of adolescents. Drug Alcohol Rev. 2003;22(3):295.CrossRefGoogle Scholar
  9. 9.
    Brewer C, Streel E, Skinner M. Supervised disulfiram’s superior effectiveness in alcoholism treatment: ethical, methodological, and psychological aspects. Alcohol Alcohol. 2017;52(2):213–9.PubMedGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of PsychiatryNew York University School of MedicineNew YorkUSA

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