Corneal Healing

  • Veronica Vargas
  • Francisco Arnalich-Montiel
  • Jorge L. Alió del Barrio
Part of the Essentials in Ophthalmology book series (ESSENTIALS)


Corneal wound healing is a complex procedure that involves apoptosis, migration, proliferation, and differentiation of cells. Several growth factors and cytokines are necessary to perform this process. Due to the avascular nature of the cornea, these growth factors proceed from sources such as tears, inflammatory cells, epithelium, or stroma. Depending on the extent and type of injury, the healing response can produce corneal scarring, with loss of corneal transparency leading to visual impairment.

In this chapter, we are going to describe the different cytokines and growth factors involved in the healing procedure, as the different phases during the recovery of each corneal layer.


Growth factors Cytokines Keratocytes Fibroblasts Myofibroblasts 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Veronica Vargas
    • 1
  • Francisco Arnalich-Montiel
    • 2
  • Jorge L. Alió del Barrio
    • 3
  1. 1.Vissum Instituto Oftalmologico de AlicanteAlicanteSpain
  2. 2.Vissum CorporationMadridSpain
  3. 3.University Miguel HernandezVissum-Instituto Oftalmologico de AlicanteAlicanteSpain

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