Selective Serotonin Reuptake Inhibitors (SSRIs) and Weight Gain

  • Leon I. IgelEmail author


A 22-year-old female college student presents for a new patient visit. She has a history of depression and class 1 obesity (height 64 in, weight 186 lb, BMI 31.9 kg/m2). The patient reports being diagnosed with depression by her prior internist, who initiated treatment with paroxetine 2 years ago. Her current dose of paroxetine is 40 mg daily. She feels that the paroxetine has improved her mood. However, she does note that since initiating the medication, she has gained 11 lb and has also experienced sexual side effects, including decreased libido. These side effects have contributed to some emotional and relationship distress. She maintains a healthy diet and exercises four to five times per week for 45–60 min per session. Despite these efforts, she has struggled to limit further weight gain. She would like to lose weight and asks for your help with respect to weight management.


Selective serotonin reuptake inhibitor (SSRI) Weight gain Depression Paroxetine Tricyclic antidepressant 


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Comprehensive Weight Control Center, Division of EndocrinologyDiabetes and Metabolism, Weill Cornell Medical CollegeNew YorkUSA

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