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BESNet: Boundary-Enhanced Segmentation of Cells in Histopathological Images

  • Hirohisa OdaEmail author
  • Holger R. Roth
  • Kosuke Chiba
  • Jure Sokolić
  • Takayuki Kitasaka
  • Masahiro Oda
  • Akinari Hinoki
  • Hiroo Uchida
  • Julia A. Schnabel
  • Kensaku Mori
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 11071)

Abstract

We propose a novel deep learning method called Boundary-Enhanced Segmentation Network (BESNet) for the detection and semantic segmentation of cells on histopathological images. The semantic segmentation of small regions using fully convolutional networks typically suffers from inaccuracies around the boundaries of small structures, like cells, because the probabilities often become blurred. In this work, we propose a new network structure that encodes input images to feature maps similar to U-net but utilizes two decoding paths that restore the original image resolution. One decoding path enhances the boundaries of cells, which can be used to improve the quality of the entire cell segmentation achieved in the other decoding path. We explore two strategies for enhancing the boundaries of cells: (1) skip connections of feature maps, and (2) adaptive weighting of loss functions. In (1), the feature maps from the boundary decoding path are concatenated with the decoding path for entire cell segmentation. In (2), an adaptive weighting of the loss for entire cell segmentation is performed when boundaries are not enhanced strongly, because detecting such parts is difficult. The detection rate of ganglion cells was 80.0% with 1.0 false positives per histopathology slice. The mean Dice index representing segmentation accuracy was 74.0%. BESNet produced a similar detection performance and higher segmentation accuracy than comparable U-net architectures without our modifications.

Notes

Acknowledgements

Parts of this research were supported by JSPS KAKENHI (26108006, 17H00867, 17K20099) and JSPS Bilateral Joint Research Project.

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Hirohisa Oda
    • 1
    Email author
  • Holger R. Roth
    • 2
  • Kosuke Chiba
    • 3
  • Jure Sokolić
    • 4
  • Takayuki Kitasaka
    • 5
  • Masahiro Oda
    • 3
  • Akinari Hinoki
    • 3
  • Hiroo Uchida
    • 3
  • Julia A. Schnabel
    • 4
  • Kensaku Mori
    • 2
    • 6
    • 7
  1. 1.Graduate School of Information ScienceNagoya UniversityNagoyaJapan
  2. 2.Graduate School of InformaticsNagoya UniversityNagoyaJapan
  3. 3.Nagoya University Graduate School of MedicineNagoyaJapan
  4. 4.Division of Imaging Sciences and Biomedical EngineeringKing’s College LondonLondonUK
  5. 5.School of Information ScienceAichi Institute of TechnologyToyotaJapan
  6. 6.Information Technology CenterNagoya UniversityNagoyaJapan
  7. 7.Research Center for Medical BigdataNational Institute of InformaticsTokyoJapan

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