Adversarial Domain Adaptation for Classification of Prostate Histopathology Whole-Slide Images

  • Jian RenEmail author
  • Ilker Hacihaliloglu
  • Eric A. Singer
  • David J. Foran
  • Xin Qi
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 11071)


Automatic and accurate Gleason grading of histopathology tissue slides is crucial for prostate cancer diagnosis, treatment, and prognosis. Usually, histopathology tissue slides from different institutions show heterogeneous appearances because of different tissue preparation and staining procedures, thus the predictable model learned from one domain may not be applicable to a new domain directly. Here we propose to adopt unsupervised domain adaptation to transfer the discriminative knowledge obtained from the source domain to the target domain without requiring labeling of images at the target domain. The adaptation is achieved through adversarial training to find an invariant feature space along with the proposed Siamese architecture on the target domain to add a regularization that is appropriate for the whole-slide images. We validate the method on two prostate cancer datasets and obtain significant classification improvement of Gleason scores as compared with the baseline models.



This research was funded, in part, by grants from NIH/NCI contracts 4R01LM009239-08, 7R01CA161375-05, 1UG3CA225021-01, and P30CA072720.


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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Jian Ren
    • 1
    Email author
  • Ilker Hacihaliloglu
    • 2
  • Eric A. Singer
    • 3
  • David J. Foran
    • 3
  • Xin Qi
    • 3
  1. 1.Department of Electrical and Computer EngineeringRutgers UniversityPiscatawayUSA
  2. 2.Department of Biomedical EngineeringRutgers UniversityPiscatawayUSA
  3. 3.Rutgers Cancer Institute of New JerseyNew BrunswickUSA

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