Physiology of the Lateral Decubitus Position, Open Chest, and One-Lung Ventilation

  • Sean R. McLean
  • Jens LohserEmail author


Ventilation and perfusion matching is optimized for gas exchange. Induction of anesthesia, one-lung ventilation (OLV), and opening of the chest progressively uncouple ventilation–perfusion (V/Q) homeostasis. Hypoxic pulmonary vasoconstriction (HPV) improves V/Q matching during OLV but can be impaired by anesthetic interventions.


One-lung ventilation Lateral decubitus position Open chest Hypoxic pulmonary vasoconstriction Ventilation–perfusion matching Thoracic surgery 


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Anesthesiology, Pharmacology, and TherapeuticsUniversity of British Columbia, Vancouver General HospitalVancouverCanada

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