The Patient with “Myelogenous Osteopathy”

  • Reiner Bartl
  • Christoph Bartl


Neumann and Bizzozero published almost simultaneously in 1868 that the bone marrow and the bone are closely interrelated organs. The term “haematic osteodysplasia” was first introduced by Gaensslen in 1938 to describe the effects on the skull caused by congenital haemolytic anaemias, i.e. the typical “hair-on-end” appearance of the cranial bones. Subsequently, Rohr in 1940 and Markoff in 1942 used the term myelogenous osteopathy and osteogenous myelopathy for osteoporosis, osteolysis and osteosclerosis occurring in myelogenous disorders and the suppression of haematopoiesis due to diseases of the bones, respectively. Based on thousands of evaluated iliac crest biopsies, Burkhardt has distinguished eight different pathogenetic mechanisms of myelogenous osteopathy, which may occur alone or in combination.


Hairy cell leukaemia Cranial bone Osseous lesion Trabecular network Iliac crest biopsy 

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Reiner Bartl
    • 1
  • Christoph Bartl
    • 1
    • 2
  1. 1.Osteoporosis and Bone CenterMunichGermany
  2. 2.Center of Orthopaedics and Sports MedicineMunichGermany

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