Biophysical and Biochemical Characteristics of Therapeutic Proteins

  • Wim JiskootEmail author
  • Daan J. A. Crommelin


Pharmaceutical proteins are large, folded structures stabilized by weak physical/chemical forces. An appreciation of the factors that may influence their structure is an absolute requirement when dealing with these complex, fragile compounds.


Protein structure Amino acids Protein folding 

Further Reading

  1. Buxbaum E (2015) Fundamentals of protein structure and function, 2nd edn. Springer, New YorkCrossRefGoogle Scholar
  2. Creighton TE (ed) (1989) Protein structure: a practical approach. IRL Press, OxfordGoogle Scholar
  3. Gregory RB (ed) (1994) Protein-solvent interactions. Marcel Dekker, New YorkGoogle Scholar
  4. Schulz GE, Schirmer RH (eds) (1979) Principles of protein structure. Springer, New YorkGoogle Scholar
  5. Shirley BA (ed) (1995) Protein stability and folding. Humana Press, TotowaGoogle Scholar
  6. Whitford D (2005) Proteins: structure and function. Wiley, Hoboken, NJGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Division of BioTherapeutics, Leiden Academic Centre for Drug Research (LACDR)Leiden UniversityLeidenThe Netherlands
  2. 2.Department of PharmaceuticsUtrecht Institute for Pharmaceutical Sciences, Utrecht UniversityUtrechtThe Netherlands

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