• Wim JiskootEmail author
  • Gideon F. A. Kersten
  • Enrico Mastrobattista
  • Bram Slütter


Since the introduction of smallpox vaccination more than two centuries ago, vaccines have been—and still are—instrumental in the prevention of infectious diseases. Nowadays vaccines form a heterogeneous group of pharmaceutical products that differ in several aspects from other biopharmaceuticals. In this chapter, after a brief introduction we first cover immunological principles that are important for vaccine design. Next, we give an overview of the different vaccine categories and current approaches to vaccine development, illustrated with representative examples. We also describe current trends in the field of vaccines against non-infectious diseases, such as therapeutic vaccines against cancer and other diseases. Moreover, routes of administration relevant to vaccination and pharmaceutical aspects of vaccines are briefly discussed.


Adjuvant Antigen Formulation Immunogenicity Immunological principles Route of administration Vaccine categories 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Wim Jiskoot
    • 1
    Email author
  • Gideon F. A. Kersten
    • 2
  • Enrico Mastrobattista
    • 3
  • Bram Slütter
    • 1
  1. 1.Division of BioTherapeutics, Leiden Academic Centre for Drug Research (LACDR)Leiden UniversityLeidenThe Netherlands
  2. 2.Institute for Translational VaccinologyBilthovenThe Netherlands
  3. 3.Department of PharmaceuticsUtrecht UniversityUtrechtThe Netherlands

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