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Critical Lipidomics: The Consequences of Lipid Miscibility in Biological Membranes

  • Sarah L. Veatch
  • Pietro Cicuta
Chapter

Abstract

There is growing evidence that cell plasma membranes exhibit significant lateral heterogeneity in the composition of lipids and concentration of proteins. These domains have sub-micron dimensions and have been implicated in vital cell functions. Similar liquid domains are also observed, with fluorescence and non-perturbative techniques such as NMR, in model bilayer membrane mixtures that mimic cellular lipid compositions. This chapter overviews the physics, biological evidence, and consequences connected to liquid immiscibility in phospholipid membranes. The presence of phase transitions close to physiological conditions and concentrations directly implies a wide phenomenology of spontaneous lipid organization and dynamics on different length-scales. The interplay of this spontaneous lipid ordering due to the miscibility transition, with protein function and other regulatory, structural, biochemical, and mechanical membrane processes, is still an open area of investigation.

Keywords

Lipid rafts Lipidomics Membrane proteins Phase separation 

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© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Departments of Biophysics and PhysicsUniversity of MichiganAnn ArborUSA
  2. 2.Cavendish LaboratoryUniversity of CambridgeCambridgeUK

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