In-Line X-Ray Phase Tomography of Bone and Biomaterials for Regenerative Medicine

  • Max LangerEmail author
Part of the Fundamental Biomedical Technologies book series (FBMT)


The aim of this chapter is to present recent developments in X-ray tomography using in-line phase contrast and their applications to mineralised tissue, whether bone or artificial biomaterials, at micro- and nanoscale. Recently, the main efforts in reconstruction algorithms for in-line X-ray phase contrast imaging have been to push resolution towards the nanoscale and extend the possibilities for quantitative imaging to more general objects. The first is made possible by the use of X-ray optics and the second by the introduction of more advanced priors in the reconstruction. We summarise here these developments and outline recent applications of these techniques, namely, nano-tomography of the ultrastructure of bone and micro-tomography of bone formation in artificial bone grafts as well as in healthy growing mice. While still relatively little used in the field of regenerative medicine, we hope that these examples will stimulate further studies in this field.


X-ray nano-tomography X-ray micro-tomography Bone formation Bone collagen Osteocytes Finite element modelling 


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Authors and Affiliations

  1. 1.Creatis, CNRS UMR 5220, INSERM U1206, INSA-LyonUniversité Claude Bernard Lyon 1, Université de LyonVilleurbanneFrance

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