Molecular Mechanisms of Hepatitis B and C Viruses Related Liver Carcinogenesis

  • C. Brechot
Conference paper
Part of the Progress in Anti-Cancer Chemotherapy book series (ANTI-CANCER, volume 3)

Abstract

Primary liver cancer is the eighth most frequent tumor world-wide but the incidence of this tumor significantly varies in different geographical areas, the highest incidence being shown in Sub-Saharian Africa and South east Asia. It is important to emphasize the heterogeneity of the histological background on which the tumor develops. Most HCCs will complicate the evolution of an active or inactive cirrhosis. However some tumors will occur on livers with minimal histological changes. A large number of epidemiological and molecular studies have indeed clearly indicated the major importance of environmental factors in the developpment of primary liver cancers in humans. Chronic infections by Hepatitis B (HBV) and C (HCV) are major risk factors (Figure 1). Although this review will mostly analyse the impact of HBV chronic infection it is important to emphasize that some chemical carcinogens are also involved, as well as, yet poorly defined, hormonal factors which would account for higher incidence of the tumor in man. Finally the role of genetic factors has been raised but is difficult to properly adress, due to several confounding variables such as intra familial transmission of HBV.

Keywords

Primary Liver Cancer Liver Carcinogenesis Woodchuck Hepatitis Virus Virus Transactivator Minimal Histological Change 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Springer-Verlag France 1999

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  • C. Brechot

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