Abstract
Clinical resistance to antitumour drugs is noted in patients previously treated not only with chemotherapy, but also with radiotherapy. We have proposed that although radiation-induced vascular fibrosis may limit drug delivery to the tumour, exposure to radiation may ≪ induce ≫ or ≪ select ≫ for drug resistance [1, 2]. We have examined this hypothesis using an in vitro model system and shown that exposure of mammalian tumour cells to fractionated X-irradiation results in the expression of resistance to a range of antitumour drugs. We have also selected for drug resistance by in vitro drug exposure and then examined the drug resistance phenotype of these various independently-derived sublines
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References
Hill BT, Deuchars K, Hosking LK et al (1990) Overexpression of P-glycoprotein in mammalian tumour cell lines after fractionated X-irradiation in vitro. J Natl Cancer Inst 82: 607–612
Hill BT, Whelan RDH, Hosking LK et al (1988) Interactions between antitumor drugs and radiation in mammalian tumour cell lines: differential drug responses and mechanisms of resistance following fractionated X-irradiation or continuous drug exposure in vitro. NCI Monogr 6: 177–181
Hill BT, Whelan RDH, Gibby EM et al (1987) Establishment and characterisation of three new human ovarian carcinoma cell lines and initial evaluation of their potential in experimental chemotherapy studies. Int J Cancer 39: 219–225
Whelan RDH, Hosking LK, Townsend AJ et al (1989) Differential increases in glutathione S-transferase activities in a range of multidrug-resistant human tumour cell lines. Cancer Commun 1: 359–365
Hill BT, McClean S, Whelan RDH (1991) Human breast cancer cells exposed in vitro to fractionated X-irradiation express drug resistance yet retain functional hormone receptors and unaltered levels of epidermal growth factor receptors. Proc Am Soc Clin Oncol 10 (in press)
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© 1991 Springer-Verlag France
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Hill, B.T., Dempke, W.C.M., Hosking, L.K., McClean, S., Whelan, R.D.H. (1991). Differential expression of P-glycoprotein and certain other multidrug resistance characteristics in tumour cells pre-exposed in vitro either to antitumour drugs or to fractionated radiation. In: Banzet, P., Holland, J.F., Khayat, D., Weil, M. (eds) Proceedings of the 3rd International Congress on Neo-Adjuvant Chemotherapy. Springer, Paris. https://doi.org/10.1007/978-2-8178-0782-9_79
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DOI: https://doi.org/10.1007/978-2-8178-0782-9_79
Publisher Name: Springer, Paris
Print ISBN: 978-2-8178-0784-3
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