Bone and Development pp 233-249

Part of the Topics in Bone Biology book series (TBB, volume 6)

| Cite as

Fibrodysplasia Ossificans Progressiva: Developmental Implications of a Novel Metamorphogene

  • Frederick S. Kaplan
  • Jay C. Groppe
  • Petra Seemann
  • Robert J. Pignolo
  • Eileen M. Shore
Chapter

Abstract

Robust developmental novelty often results from polymorphisms or mutations in the regulatory regions of genes that control major morphogenetic signaling pathways [77]. It is much more unusual for developmental novelty to arise from mutations in the protein-coding region of such genes, because they often lead to embryonic death or catastrophic postnatal phenotypes.

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© Springer-Verlag London 2010

Authors and Affiliations

  • Frederick S. Kaplan
    • 1
  • Jay C. Groppe
    • 2
  • Petra Seemann
    • 3
  • Robert J. Pignolo
    • 4
  • Eileen M. Shore
    • 5
  1. 1.Division of Molecular Orthopaedic Medicine Department of Orthopaedic SurgeryThe University of Pennsylvania School of MedicinePhiladelphiaUSA
  2. 2.Department of Biomedical Sciences Baylor College of DentistryTexas A&M University Health Science CenterDallasUSA
  3. 3.Berlin-Brandenburg Center for Regenerative TherapiesInstitution Charité Universitätsmedizin BerlinBerlinGER
  4. 4.Department of MedicineUniversity of Pennsylvania School of MedicinePhiladelphiaUSA
  5. 5.Department of Orthopaedic SurgeryUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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