Transforming “Waste” into Gold: Identification of Novel Stem Cells Resources with Therapeutic Potential in Neuromuscular Disorders

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Abstract

Once considered a biological waste product, umbilical cord blood (UCB) has emerged as a viable source of hematopoietic stem cells for transplantation. At the time of World War II, stored placental blood was explored as a source of blood for transfusion, and found to be similar in effect to fresh adult blood. During the 1970s, it was recognized that UCB contains hematopoietic progenitor cells. The suggestion that cryopreserved UCB could be used as a source of stem cells in much the same way as transplantation of bone marrow paved the way for the first successful human UCB transplant, performed in France in 1988. The recipient remains alive and well 18 years later. Since then, more than 2,000 transplants have been performed worldwide, most using stored units in private or public cord blood banks.

Keywords

Mesenchymal Stem Cell Umbilical Cord Umbilical Cord Blood Hematopoietic Progenitor Cell Bone Marrow MSCs 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer London 2011

Authors and Affiliations

  1. 1.Department of Genetic and Evolutive Biology, Human Genome Research CenterUniversity of São PauloSão PauloBrazil

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