Physiology and Pharmacology of the Bladder

  • Karl-Erik Andersson
Chapter
First Online:
Part of the Springer Specialist Surgery Series book series (SPECIALIST)

Abstract

The functions of the lower urinary tract (LUT) are to store and periodically release urine. These functions are dependent upon a complex interplay between the central and peripheral nervous systems and local regulatory factors.1 The neural circuitry that controls these interactions is complex and involves pathways at many levels of the brain, the spinal cord, and the peripheral nervous system, and it is mediated by multiple neurotransmitters. Micturition is under voluntary control and depends on learned behavior that develops during maturation of the nervous system. Normal micturition requires coordination of the activity of the bladder and urethra with that of urethral striated muscle, and depends on the integration of pontine centers and autonomic and somatic efferent mechanisms within the lumbosacral spinal cord (see Fowler et al.2).

Keywords

Muscarinic Receptor Lower Urinary Tract Nicotinic Receptor Detrusor Overactivity Human Bladder 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer London 2011

Authors and Affiliations

  • Karl-Erik Andersson
    • 1
  1. 1.Institute for Regenerative MedicineWake Forest University Medical SchoolWinston SalemUSA

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