Immunobiology and Immune-Based Therapies of Melanoma

  • Mariah R. Brown
  • John C. Ansel
  • Cheryl A. Armstrong
  • Human regulatory T cells (Tregs) play an important role in suppressing antitumor immune responses.

  • Melanoma-derived factors may convert dendritic cells into tolerance-inducing, antigen-presenting cells.

  • Adhesion molecules such as integrins, cadherins, and intercellular adhesion molecule 1 (ICAM-1) have been implicated in progression of melanoma.

  • Melanoma cells produce a variety of cytokines that allow tumor progression.

  • Surgery, chemotherapy, and immunotherapy (e.g., interferon-α and interleukin-2) are used in the treatment of melanoma.

  • A variety of vaccines are being studied for therapy of melanoma.


Melanoma Cell Clin Oncol Metastatic Melanoma Melanoma Patient Newcastle Disease Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag London Limited 2008

Authors and Affiliations

  • Mariah R. Brown
    • 1
  • John C. Ansel
    • 1
  • Cheryl A. Armstrong
    • 1
  1. 1.Department of DermatologyUniversity of Colorado at Denver and Health Sciences CenterAuroraUSA

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