A Description of the Pioneering Work That Led to the First Approved Agents for ED: Giles Brindley, the Needle, and the Penis (Phenoxybenzamine)


Although some earlier work had been described by Virag, this study really laid down the foundation for the use of therapeutics in the management of ED. It encouraged both patients and physicians to believe that there was a realistic alternative to corrective or implant surgery.


Erectile Dysfunction Penile Erection Realistic Alternative Local Adverse Event Unstriated Muscle 
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2.1 Key Trial References

2.1.1 Major Publication

  1. Brindley G. Cavernosal alpha-blockade: a new technique for investigating and treating erectile dysfunction. Br J Psychiat 143:332–337, 1983.Google Scholar

2.1.2 Other Important Publications

  1. Virag R. Intracavernous injection of papaverine for erectile failure. Lancet ii, 938, 1982.CrossRefGoogle Scholar
  2. Brindley G. Maintenance treatment of erectile impotence by cavernosal unstriated muscle relaxant injection. Br J Psychiat 149:210–215, 1986.CrossRefGoogle Scholar
  3. Keogh E, Earle C, et al. Treatment of impotence by intrapenile injections of papaverine and phenoxybenzamine: a double-blind controlled trial. Aust NZ J Med 19(2):108–112, 1989.Google Scholar

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© Springer-Verlag London Limited 2007

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