Effects of Flaxseed on Cardiovascular Disease Risk Factors in Menopause

  • Maureen Meister
  • Brenda J. Smith
  • Bahram H. Arjmandi
  • Edralin A. LucasEmail author
Part of the Nutrition and Health book series (NH)

Key Points

  • Both animal and human studies indicate that flaxseed may reduce CVD risk factors in ovarian hormone deficiency.

  • Most of the observed positive effect of flaxseed in postmenopausal women is on their ability to improve lipid profile.

  • Whole flaxseed seems to be more beneficial than its isolated components such as the lignan, secoisolariceresinol diglucoside (SDG), its oil, or fiber.

  • Results of clinical studies demonstrate that flaxseed can be a part of a heart healthy diet of postmenopausal women.

  • Further research is needed to understand the mechanism(s) by which flaxseed lowers CVD risk factors in ovarian hormone deficiency.


Flaxseed Cardiovascular disease Menopause Lignans α-Linolenic acid Secoisola­riciresinol diglucoside 



Cardiovascular disease


Low-density lipoprotein


High-density lipoprotein


Hormone replacement therapy


Secoisolariciresinol diglucoside


α-Linolenic acid


Soluble cell adhesion molecules


von Willebrand factor






Whole flaxseed


Flaxseed oil


Lipoprotein (a)


C-Reactive protein


Eicosapentanoic acid


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Maureen Meister
    • 1
  • Brenda J. Smith
    • 2
  • Bahram H. Arjmandi
    • 3
  • Edralin A. Lucas
    • 4
    Email author
  1. 1.Nutritional Sciences DepartmentOklahoma State UniversityStillwaterUSA
  2. 2.Nutritional Sciences DepartmentOklahoma State UniversityStillwaterUSA
  3. 3.Department of Nutrition, Food and ExerciseFlorida State UniversityTallahasseeUSA
  4. 4.Nutritional Sciences DepartmentOklahoma State UniversityStillwaterUSA

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