Vitamin K Deficiency and its Prevention and Treatment in Infants

Chapter
Part of the Nutrition and Health book series (NH)

Abstract

Vitamin K (VK) is the name for a group of fat-soluble organic substances that consist of a 2-methyl-1,4-naphthoquinone ring structure with differing carbon side chains at the 3-position.

Keywords

Hemorrhagic disease of the newborn Vitamin K Vitamin K deficiency bleeding Vitamin K prophylaxis Proteins induced by vitamin K absence or antagonism PIVKA 

References

  1. 1.
    Pazirandeh S, Burns DL. Overview of vitamin K. http://www.uptodate.com/index. Accessed 1 June 2011.
  2. 2.
    Watanbe K, Yasugi E, Oshima M. How to search the glycolipids data in ‘LIPIDBANK for Web’: the newly developed lipid database in Japan. Trends Glycosci Glycotechnol. 2000;12:175–84. http://lipidbank.jp/. Accessed 1 June 2011.
  3. 3.
    Hey E. Vitamin K—what, why and when. Arch Dis Child Fetal Neonatal Ed. 2003;88:F80–3.PubMedCrossRefGoogle Scholar
  4. 4.
    Merrifield LS, Yang HY. Vitamin K5 as a fungistatic agent. Appl Microbiol. 1965;13:660–2.PubMedGoogle Scholar
  5. 5.
    Richardson W. Charles Wendell townsend. N Engl J Med. 1953;248:28–9.PubMedCrossRefGoogle Scholar
  6. 6.
    Townsend CW. The haemorrhagic disease of the new-born. Arch Pediatr. 1894;11:559–65.Google Scholar
  7. 7.
    Dam H, Schønheyder F. The occurrence and chemical nature of vitamin K. Biochem J. 1936;30:897–901.PubMedGoogle Scholar
  8. 8.
    Doisy EA, Binkley SB, Thayer SA, McKee RW. Vitamin K. Science. 1940;91:58–62.PubMedCrossRefGoogle Scholar
  9. 9.
    Dam H. Nobel lecture: the discovery of vitamin K, its biological functions and therapeutical application. http://nobelprize.org/nobel_prizes/medicine/laureates/. Accessed 1 June 2011.
  10. 10.
    Warner ED, Brinkhous KM, Smith HP. Bleeding tendency of obstructive jaundice: prothrombin deficiency and dietary factors. Proc Soc Exp Biol Med. 1938;37:628–30.Google Scholar
  11. 11.
    Pichler E, Pichler L. The neonatal coagulation system and the vitamin K deficiency bleeding—a mini review. Wien Med Wochenschr. 2008;158:385–95.PubMedCrossRefGoogle Scholar
  12. 12.
    Nelsestuen GL, Zytkovicz TH, Howard JB. The mode of action of vitamin K. Identification of gamma-carboxyglutamic acid as a component of prothrombin. J Biol Chem. 1974;249:6347–50.PubMedGoogle Scholar
  13. 13.
    Greer FR. Vitamin K, the basics—what’s new? Early Hum Dev. 2010;86:S43–7.CrossRefGoogle Scholar
  14. 14.
    Mann KG. Biochemistry and physiology of blood coagulation. Thromb Haemost. 1999;82:165–74.PubMedGoogle Scholar
  15. 15.
    Van Winckel M, De Bruyne R, Van De Velde S, Van Biervliet S. Vitamin K, an update for the paediatrician. Eur J Pediatr. 2009;168:127–34.PubMedCrossRefGoogle Scholar
  16. 16.
    Sadler JE. Medicine: K is for koagulation. Nature. 2004;427:493–4.PubMedCrossRefGoogle Scholar
  17. 17.
    Stafford DW. The vitamin K cycle. J Thromb Haemost. 2005;3:1873–8.PubMedCrossRefGoogle Scholar
  18. 18.
    Li T, Chang CY, Jin DY, Lin PJ, Khvorova A, Stafford DW. Identification of the gene for vitamin K epoxide reductase. Nature. 2004;427:541–4.PubMedCrossRefGoogle Scholar
  19. 19.
    Wadelius M, Chen LY, Downes K, Ghori J, Hunt S, Eriksson N, et al. Common VKORC1 and GGCX polymorphisms associated with warfarin dose. Pharmacogenomics J. 2005;5:262–70.PubMedCrossRefGoogle Scholar
  20. 20.
    Napolitano M, Mariani G, Lapecorella M. Hereditary combined deficiency of the vitamin K-dependent clotting factors. Orphanet J Rare Dis. 2010;5:21.PubMedCrossRefGoogle Scholar
  21. 21.
    Sutor AH, von Kries R, Cornelissen EA, McNinch AW, Andrew M. Vitamin K deficiency bleeding (VKDB) in infancy. ISTH Pediatric/Perinatal Subcommittee. International Society on Thrombosis and Haemostasis. Thromb Haemost. 1999;81:456–61.PubMedGoogle Scholar
  22. 22.
    Greer FR. Vitamin K, status of lactating mothers and their infants. Acta Paediatr Suppl. 1999;88:95–103.PubMedCrossRefGoogle Scholar
  23. 23.
    Crawford PM. Managing epilepsy in women of childbearing age. Drug Saf. 2009;32:293–307.PubMedCrossRefGoogle Scholar
  24. 24.
    Yamasamit W, Chaithongwongwatthana S, Tolosa JE. Prenatal vitamin K1 administration in epileptic women to prevent neonatal hemorrhage: is it effective? J Reprod Med. 2006;51:463–6.Google Scholar
  25. 25.
    Crowther CA, Crosby DD, Henderson-Smart DJ. Vitamin K prior to preterm birth for preventing neonatal periventricular haemorrhage. Cochrane Database Syst Rev. 2010;(1):CD000229.Google Scholar
  26. 26.
    Leaf AA. RCPCH Standing Committee on Nutrition. Vitamins for babies and young children. Arch Dis Child. 2007;92:160–4.PubMedCrossRefGoogle Scholar
  27. 27.
    Shearer MJ. Vitamin K, deficiency bleeding (VKDB) in early infancy. Blood Rev. 2009;23:49–59.PubMedCrossRefGoogle Scholar
  28. 28.
    D’Souza IE, Rao SD. Late hemorrhagic disease of the newborn. Indian Pediatr. 2003;40:226–9.PubMedGoogle Scholar
  29. 29.
    Suzuki S, Iwata G, Sutor AH. Vitamin K deficiency during the perinatal and infantile period. Semin Thromb Hemost. 2001;27:93–8.PubMedCrossRefGoogle Scholar
  30. 30.
    Roberts IA, Murray NA. Chapter 30: haematology. In: Rennie JM, editor. Roberton’s textbook of neonatology. 4th ed. Philadelphia: Elsevier Churchill Livingstone; 2005. p. 739–72.Google Scholar
  31. 31.
    Greer FR. Are breast-fed infants vitamin K deficient? Adv Exp Med Biol. 2001;501:391–5.PubMedCrossRefGoogle Scholar
  32. 32.
    Isarangkura P, Mahasandana C, Chuansumrit A, Angchaisuksiri P. Acquired bleeding disorders: the impact of health problems in the developing world. Haemophilia. 2004;10:S188–95.CrossRefGoogle Scholar
  33. 33.
    Victora CG, Van Haecke P. Vitamin K prophylaxis in less developed countries: policy issues and relevance to breastfeeding promotion. Am J Public Health. 1998;88:203–9.PubMedCrossRefGoogle Scholar
  34. 34.
    Busfield A, McNinch A, Tripp J. Neonatal vitamin K prophylaxis in Great Britain and Ireland: the impact of perceived risk and product licensing on effectiveness. Arch Dis Child. 2007;92:754–8.PubMedCrossRefGoogle Scholar
  35. 35.
    Clarke P, Shearer MJ. Vitamin K deficiency bleeding: the readiness is all. Arch Dis Child. 2007;92:741–3.PubMedCrossRefGoogle Scholar
  36. 36.
    McNinch A, Busfield A, Tripp J. Vitamin K deficiency bleeding in Great Britain and Ireland: British Paediatric Surveillance Unit surveys, 1993–1994 and 2001–2002. Arch Dis Child. 2007;92:759–66.PubMedCrossRefGoogle Scholar
  37. 37.
    Golding J, Paterson M, Kinlen LJ. Factors associated with childhood cancer in a national cohort study. Br J Cancer. 1990;62:304–8.PubMedCrossRefGoogle Scholar
  38. 38.
    Autret-Leca E, Jonville-Bera AP. Vitamin K in neonates: how to administer, when and to whom. Paediatr Drugs. 2001;3:1–8.PubMedCrossRefGoogle Scholar
  39. 39.
    Von Kries R. Oral versus intramuscular phytomenadione: safety and efficacy compared. Drug Saf. 1999;21:1–6.CrossRefGoogle Scholar
  40. 40.
    Strehle EM, Howey C, Jones R. Evaluation of the acceptability of a new oral vitamin K prophylaxis for breastfed infants. Acta Paediatr. 2010;99:379–83.PubMedCrossRefGoogle Scholar
  41. 41.
    Sutor AH. New aspects of vitamin K prophylaxis. Semin Thromb Hemost. 2003;29:373–6.PubMedCrossRefGoogle Scholar
  42. 42.
    Bhandari V, Tin NO, Ahmed SR. Aspiration pneumonia in association with oral vitamin K. Arch Dis Child Fetal Neonatal Ed. 2002;87:F232.PubMedCrossRefGoogle Scholar
  43. 43.
    Philip RK, Gul R, Dunworth M, Keane N. Ireland lacks consensus on neonatal vitamin K prophylaxis. BMJ. 2001;323:1068.PubMedCrossRefGoogle Scholar
  44. 44.
    Puckett RM, Offringa M. Prophylactic vitamin K for vitamin K deficiency bleeding in neonates. Cochrane Database Syst Rev. 2000;(4):CD002776.Google Scholar
  45. 45.
    Drug Reference Encyclopedia: AquaMEPHYTON Injection (Merck). Issued February 2002. http://www.theodora.com/drugs/aquamephyton_injection_merck.html. Accessed 1 June 2011.
  46. 46.
    Martin J ed. British National Formulary March 2011. Chapter 9.6.6: vitamin K. London: BMJ Group; 2011: 620–1.Google Scholar
  47. 47.
    MHRA. NEOKAY 1MG CAPSULES PL 04532/0012 UKPAR. London, 2010. http://www.mhra.gov.uk/SearchHelp/Search/Searchresults/index.htm?within=Yes%26keywords=Neokay. Accessed 31 June 2011.
  48. 48.
    Tripp JH, McNinch AW. Haemorrhagic disease and vitamin K. Arch Dis Child. 1987;62:436–7.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Northumbria Healthcare NHS Foundation Trust, The Newcastle Hospitals NHS Foundation Trust and The Medical SchoolNewcastle University, North Tyneside General HospitalNewcastle-Upon-TyneUK

Personalised recommendations