Nutrition in Infancy pp 307-317 | Cite as
Exposure to Breast Milk in Infancy and Risk of Adult Breast Cancer: A Summary of the Evidence
Abstract
There has been considerable interest in the health-related benefits of breastfeeding for the infant. While there are many established short-term benefits of breastfeeding for infant nutrition and health [1], the potential long-term benefits regarding chronic disease and cancer morbidity in adulthood, including risk of breast cancer, are still unclear. In this chapter, we review the epidemiologic evidence regarding the association between being breastfed in infancy and risk of short-term and long-term health outcomes, focusing specifically on adult breast cancer. We also present the results of a meta-analysis of published studies on breastfeeding in infancy and risk of adult breast cancer, updating a 2005 meta-analysis on this topic [2]. Finally, we make recommendations for improving future epidemiologic studies that investigate the effects of exposure to breast milk in infancy on longer-term health.
Keywords
Breast cancer Lactation Breastfeeding Menopausal status Risk factorsAbbreviations
- RR
Relative risk
- CI
Confidence interval
- US
United States
References
- 1.Ip S, Chung M, Raman G, et al. Breastfeeding and maternal and infant health outcomes in developed countries. Evidence Report/Technology Assessment No. 153 (prepared by Tufts-New England Medical Center Evidence-based Practice Center, under Contract No. 290-02-0022). AHRQ publication no. 07-E007. Rockville, MD: Agency for Healthcare Research and Quality; 2007.Google Scholar
- 2.Martin RM, Middleton N, Gunnell D, Owen CG, Smith GD. Breast-feeding and cancer: the Boyd Orr cohort and a systematic review with meta-analysis. J Natl Cancer Inst. 2005;97:1446–57.PubMedCrossRefGoogle Scholar
- 3.Position of the American Dietetic Association. Promoting and supporting breastfeeding. J Am Diet Assoc. 2005;105:810–8.CrossRefGoogle Scholar
- 4.World Health Organization. Global strategy for infant and young child feeding. World Health Organization. Geneva, Switzerland; 2003.Google Scholar
- 5.Holme A, MacArthur C, Lancashire R. The effects of breastfeeding on cognitive and neurological development of children at 9 years. Child Care Health Dev. 2010;36:583–90.PubMedCrossRefGoogle Scholar
- 6.Jedrychowski W, Perera F, Jankowski J, et al. Effect of exclusive breastfeeding on the development of children’s cognitive function in the Krakow prospective birth cohort study. Eur J Pediatr. 2012;171(1):151–8.PubMedCrossRefGoogle Scholar
- 7.Clark KM, Castillo M, Calatroni A, et al. Breast-feeding and mental and motor development at 51/2 years. Ambul Pediatr. 2006;6:65–71.PubMedCrossRefGoogle Scholar
- 8.Slykerman RF, Thompson JM, Becroft DM, et al. Breastfeeding and intelligence of preschool children. Acta Paediatr. 2005;94:832–7.PubMedCrossRefGoogle Scholar
- 9.Smith MM, Durkin M, Hinton VJ, Bellinger D, Kuhn L. Influence of breastfeeding on cognitive outcomes at age 6–8 years: follow-up of very low birth weight infants. Am J Epidemiol. 2003;158:1075–82.PubMedCrossRefGoogle Scholar
- 10.Jiang M, Foster EM, Gibson-Davis CM. Breastfeeding and the child cognitive outcomes: a propensity score matching approach. Matern Child Health J. 2011;15(8):1296–307.PubMedCrossRefGoogle Scholar
- 11.McCrory C, Layte R. The effect of breastfeeding on children’s educational test scores at nine years of age: results of an Irish cohort study. Soc Sci Med. 2011;72:1515–21.PubMedCrossRefGoogle Scholar
- 12.Veena SR, Krishnaveni GV, Srinivasan K, et al. Infant feeding practice and childhood cognitive performance in South India. Arch Dis Child. 2010;95:347–54.PubMedCrossRefGoogle Scholar
- 13.Bartels M, van Beijsterveldt CE, Boomsma DI. Breastfeeding, maternal education and cognitive function: a prospective study in twins. Behav Genet. 2009;39:616–22.PubMedCrossRefGoogle Scholar
- 14.Kramer MS, Aboud F, Mironova E, et al. Breastfeeding and child cognitive development: new evidence from a large randomized trial. Arch Gen Psychiatry. 2008;65:578–84.PubMedCrossRefGoogle Scholar
- 15.Kramer MS, Matush L, Vanilovich I, et al. Effect of prolonged and exclusive breast feeding on risk of allergy and asthma: cluster randomised trial. BMJ. 2007;335:815.PubMedCrossRefGoogle Scholar
- 16.Kramer MS, Matush L, Vanilovich I, et al. Effects of prolonged and exclusive breastfeeding on child height, weight, adiposity, and blood pressure at age 6.5 y: evidence from a large randomized trial. Am J Clin Nutr. 2007;86:1717–21.PubMedGoogle Scholar
- 17.Kramer MS, Fombonne E, Igumnov S, et al. Effects of prolonged and exclusive breastfeeding on child behavior and maternal adjustment: evidence from a large, randomized trial. Pediatrics. 2008;121:e435–40.PubMedCrossRefGoogle Scholar
- 18.Sorensen HT, Lash TL, Rothman KJ. Beyond randomized controlled trials: a critical comparison of trials with nonrandomized studies. Hepatology. 2006;44:1075–82.PubMedCrossRefGoogle Scholar
- 19.Owen CG, Whincup PH, Kaye SJ, et al. Does initial breastfeeding lead to lower blood cholesterol in adult life? A quantitative review of the evidence. Am J Clin Nutr. 2008;88:305–14.PubMedGoogle Scholar
- 20.Martin RM, Gunnell D, Davey Smith G. Breastfeeding in infancy and blood pressure in later life: systematic review and meta-analysis. Am J Epidemiol. 2005;161:15–26.PubMedCrossRefGoogle Scholar
- 21.Owen CG, Martin RM, Whincup PH, Smith GD, Cook DG. Does breastfeeding influence risk of type 2 diabetes in later life? A quantitative analysis of published evidence. Am J Clin Nutr. 2006;84:1043–54.PubMedGoogle Scholar
- 22.Owen CG, Martin RM, Whincup PH, Smith GD, Cook DG. Effect of infant feeding on the risk of obesity across the life course: a quantitative review of published evidence. Pediatrics. 2005;115:1367–77.PubMedCrossRefGoogle Scholar
- 23.Nichols HB, Trentham-Dietz A, Sprague BL, Hampton JM, Titus-Ernstoff L, Newcomb PA. Effects of birth order and maternal age on breast cancer risk: modification by whether women had been breast-fed. Epidemiology. 2008;19:417–23.PubMedCrossRefGoogle Scholar
- 24.Barba M, McCann S, Nie J, et al. Perinatal exposures and breast cancer risk in the Western New York Exposures and Breast Cancer (WEB) Study. Cancer Causes Control. 2006;17:395–401.PubMedCrossRefGoogle Scholar
- 25.Bucalossi P, Veronesi U. Some observations on cancer of the breast in mothers and daughters. Br J Cancer. 1957;11:337–47.PubMedCrossRefGoogle Scholar
- 26.Ekbom A, Hsieh CC, Trichopoulos D, Yen YY, Petridou E, Adami HO. Breast-feeding and breast cancer in the offspring. Br J Cancer. 1993;67:842–5.PubMedCrossRefGoogle Scholar
- 27.Freudenheim JL, Marshall JR, Graham S, et al. Exposure to breastmilk in infancy and the risk of breast cancer. Epidemiology. 1994;5:324–31.PubMedCrossRefGoogle Scholar
- 28.Michels KB, Trichopoulos D, Rosner BA, et al. Being breastfed in infancy and breast cancer incidence in adult life: results from the two nurses’ health studies. Am J Epidemiol. 2001;153:275–83.PubMedCrossRefGoogle Scholar
- 29.Penrose LS, MacKenzie HJ, Karn MN. A genetical study of human mammary cancer. Br J Cancer. 1948;2:168–76.PubMedCrossRefGoogle Scholar
- 30.Sanderson M, Williams MA, Daling JR, et al. Maternal factors and breast cancer risk among young women. Paediatr Perinat Epidemiol. 1998;12:397–407.PubMedCrossRefGoogle Scholar
- 31.Titus-Ernstoff L, Egan KM, Newcomb PA, et al. Exposure to breast milk in infancy and adult breast cancer risk. J Natl Cancer Inst. 1998;90:921–4.PubMedCrossRefGoogle Scholar
- 32.Tokuhata GK. Morbidity and mortality among offspring of breast cancer mothers. Am J Epidemiol. 1969;89:139–53.PubMedGoogle Scholar
- 33.Weiss HA, Potischman NA, Brinton LA, et al. Prenatal and perinatal risk factors for breast cancer in young women. Epidemiology. 1997;8:181–7.PubMedCrossRefGoogle Scholar
- 34.Wise LA, Titus-Ernstoff L, Newcomb PA, et al. Exposure to breast milk in infancy and risk of breast cancer. Cancer Causes Control. 2009;20:1083–90.PubMedCrossRefGoogle Scholar
- 35.Henderson BE, Powell D, Rosario I, et al. An epidemiologic study of breast cancer. J Natl Cancer Inst. 1974;53:609–14.PubMedGoogle Scholar
- 36.Brinton LA, Hoover R, Fraumeni Jr JF. Reproductive factors in the aetiology of breast cancer. Br J Cancer. 1983;47:757–62.PubMedCrossRefGoogle Scholar
- 37.Harris R, Bradburn M, Deeks J, Harbord R, Altman D, Sterne J. Metan: fixed- and random-effects meta-analysis. Stata J. 2008;8:3–28.Google Scholar
- 38.Landrigan PJ, Sonawane B, Mattison D, McCally M, Garg A. Chemical contaminants in breast milk and their impacts on children’s health: an overview. Environ Health Perspect. 2002;110:A313–5.PubMedCrossRefGoogle Scholar
- 39.Stefanidou M, Maravelias C, Spiliopoulou C. Human exposure to endocrine disruptors and breast milk. Endocr Metab Immune Disord Drug Targets. 2009;9:269–76.PubMedGoogle Scholar
- 40.Darbre PD. Environmental contaminants in milk: the problem of organochlorine xenobiotics. Biochem Soc Trans. 1998;26:106–12.PubMedGoogle Scholar
- 41.Jensen AA, Slorach SA. Chemical contaminants in human milk. Bocan, FL: CRC Press; 1991.Google Scholar
- 42.Bittner JJ. Some possible effects of nursing on the mammary gland tumor incidence in mice. Science. 1936;84:162–3.PubMedCrossRefGoogle Scholar
- 43.Håkansson A, Andréasson J, Zhivotovsky B, Karpman D, Orrenius S, Svanborg C. Multimeric [alpha]-lactalbumin from human milk induces apoptosis through a direct effect on cell nuclei. Exp Cell Res. 1999;246:451–60.PubMedCrossRefGoogle Scholar
- 44.Rodriguez-Palmero M, Koletzko B, Kunz C, Jensen R. Nutritional and biochemical properties of human milk: II. Lipids, micronutrients, and bioactive factors. Clin Perinatol. 1999;26:335–59.PubMedGoogle Scholar
- 45.Ito S. Breast cancer risk and history of being breast-fed. Epidemiology. 2009;20:155. doi: 10.1097/EDE.0b013e3181907a8c.PubMedCrossRefGoogle Scholar
- 46.Centers for Disease Control and Prevention. National immunization survey. 2003. http://www.cdc.gov/breastfeeding/NIS_data. Accessed 2 Sept 2009.