Folate Nutrition in Skin Health and Skin Cancer Prevention

  • Yira Bermudez
  • Katharine Cordova
  • Joshua D. Williams
Part of the Nutrition and Health book series (NH)


This chapter will discuss the role of folate nutrition in the unique environment of human skin. The folates are a family of structurally similar, water-soluble, B vitamins, which have been well documented as vital in promoting human health and preventing disease. Optimized folate nutrient levels support many biochemical processes important for the maintenance and function of healthy skin. This importance is underscored by potential links between folate deficiency and psoriasis, vitiligo, exfoliative dermatitis, glossitis, and skin cancers. Human skin is particularly prone to the development of carcinomas. It is established that skin cancer risk correlates with exposure to the complete carcinogen, ultraviolet radiation (UVR) from sunlight. Total avoidance of solar exposure is impractical.


Folate Skin physiology Dermatology Skin cancer Folic acid 













Aminoimidazol-4-carboxamide ribonucleotide


Dihydrofolate reductase


Deoxythymidylate monophosphate


Deoxyuridylate monophosphate


N-Formylaminoimidazol-4-carboxamide ribonucleotide


Food and Drug Administration


N-Formylglycinamide ribonucleotide


Folate receptor




Folate receptor alpha


Glycinamide ribonucleotide


Gamma(γ)-glutamyl hydrolase






Heme carrier protein




Human proton coupled folate transporters


Methionine synthase


Methylenetetrahydrofolate reductase




Nicotinamide adenine dinucleotide phosphate


Atmospheric oxygen




Reactive carbonyl species


Recommended dietary allowances


Reduced folate carrier


Reactive oxygen species






Sun protection factor


Thymidylate synthase




Ultraviolet light wavelength A (315–400 nm)


Ultraviolet light wavelength B (280–315 nm)


Ultraviolet light wavelength C (100–280 nm)


Ultraviolet radiation


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Yira Bermudez
    • 1
  • Katharine Cordova
    • 2
  • Joshua D. Williams
    • 1
  1. 1.Department of Cancer Prevention and ControlThe University of Arizona Cancer CenterTucsonUSA
  2. 2.Dermatology Professionals IncorporatedEast GreenwichUSA

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