The Centrosome pp 285-305 | Cite as

Mechanisms and Consequences of Centrosome Clustering in Cancer Cells

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Abstract

Ever since initially proposed by Theodor Boveri in 1914, centrosome abnormalities have been accused to be involved in the induction of chromosomal instability and tumorigenesis. New evidence especially on a mechanism termed centrosomal clustering now again supports Boveri's idea and adds fuel to the old debate on a mechanistic link between supernumerary centrosomes and malignant transformation. On top, inhibiting centrosome clustering might well turn out to be one of the long sought after possibilities to specifically interfere with tumor cells while leaving healthy tissues untouched.

Keywords

Spindle Pole Spindle Assembly Checkpoint Centrosome Amplification Centrosome Duplication Stem Cell Division 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Notes

Acknowledgment

We apologize to those authors whose work is not cited because of space limitations. This work was supported by the Deutsche Forschungsgemeinschaft, the Deutsche Krebshilfe, the Deutsche José Carreras Leukämie-Stiftung and the Interdisciplinary Research Program of the National Center for Tumor Diseases Heidelberg.

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© Humana Press, a part of Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Clinical Cooperation Unit Molecular Hematology/OncologyGerman Cancer Research Center and Department of Internal Medicine University of HeidelbergHeidelbergGermany

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