Therapeutic Targeting of the Actin Cytoskeleton in Cancer

  • Teresa Bonello
  • Jason Coombes
  • Galina Schevzov
  • Peter Gunning
  • Justine Stehn


In cancer, actin filament populations and associated remodelling proteins are involved in driving proliferation, apoptosis and motility. Furthermore, a web of signalling pathways converge with the actin cytoskeleton to regulate these functions. Importantly, the actin cytoskeleton is a heterogeneous assembly of filament populations, each contributing to shared and unique cellular functions. The current range of actin-disrupting compounds are limited in their therapeutic use as they cannot discriminate between functionally specific populations of actin. Universal disruption of actin is likely to be intolerable in a clinical setting. Dissecting the regulation and composition of these filament populations will allow for treatments tailored to target the unique cytoskeletal repertoire of tumour cells. Identifying specific actin filament populations which are indispensible for tumour cell function is the focus of current work.


Actin Filament Actin Cytoskeleton Mitochondrial Permeability Transition Pore Actin Assembly Pocket Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Teresa Bonello
    • 1
  • Jason Coombes
    • 1
  • Galina Schevzov
    • 1
  • Peter Gunning
    • 1
  • Justine Stehn
    • 2
    • 1
  1. 1.School of Medical SciencesUniversity of New South WalesSydneyAustralia
  2. 2.Department of Pharmacology, School of Medical Sciences, Oncology Research UnitUniversity of New South WalesSydneyAustralia

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