Lung Cancer

Chapter
Part of the Respiratory Medicine book series (RM)

Abstract

As the most common type of malignancy, lung cancer is regularly encountered by primary care physicians, pulmonologists, as well as radiologists during their routine practice. Many lung cancers are detected incidentally or when patients present with symptoms related to either local or systemic effects of a tumor. Imaging plays an important role in lung cancer staging through the characterization of the primary tumor, evaluation of nodal disease, and the detection of distant metastases. Imaging guidance can also provide a means for obtaining tissue diagnosis, both for the primary or metastatic lesions.

Keywords

Lung cancer Computed tomography CT FDG-PET PET/CT Staging Screening 

References

  1. 1.
    American Cancer Society. What are the key statistics about lung cancer? 2000. http://www.cancer.org/Cancer/LungCancer-Non-SmallCell/DetailedGuide/non-small-cell-lung-cancer-key-statistics. Accessed 6 June 2011.
  2. 2.
    American College of Radiology Appropriateness Criteria. Clinical condition: solitary pulmonary nodule. 2011. http://acsearch.acr.org/TopicList.aspx?topic_all=&topic_any=‘%22lung+cancer*%22’&connector=+And+&cid=0. Accessed 6 June 2011.
  3. 3.
    Lowe VJ, Hoffman JM, DeLong DM, et al. Semiquantitative and visual analysis of FDG-PET images in pulmonary abnormalities. J Nucl Med. 1994;35:1771–6.PubMedGoogle Scholar
  4. 4.
    Turkington TG, Adams MC, Wilson JM, Wong TZ. A systematic review of factors affecting accuracy of SUV measurements. Am J Roentgenol. 2010;195:310–20.CrossRefGoogle Scholar
  5. 5.
    Troung MT, Viswanathan C, Erasmus JJ. Positron emission tomography/computed tomography in lung cancer staging, prognosis, and assessment of therapeutic response. J Thorac Imaging. 2011;26:132–46.CrossRefGoogle Scholar
  6. 6.
    Gould MK, Fletcher J, Iannettoni MD, et al. Evaluation of patients with pulmonary nodules: when is it lung cancer? ACCP evidence-based clinical practice guidelines (2nd ed.). Chest. 2007;132:108S–130S. http://chestjournal.chestpubs.org/content/132/3_suppl/108S.full. Accessed 6 June 2011.
  7. 7.
    Rivera MP, Mehta AC. Initial diagnosis of lung cancer: ACCP evidence-based clinical practice guidelines (2nd ed.). Chest. 2007;132:131S–148S. http://chestjournal.chestpubs.org/content/132/3_suppl/131S.full. Accessed June 6 2011.
  8. 8.
  9. 9.
    Fontana R, Sanderson DR, Woolner LB, et al. Lung cancer screening: the Mayo program. J Occup Med. 1986;28:746–50.PubMedCrossRefGoogle Scholar
  10. 10.
    Fontana RS, Sanderson DR, Taylor WF, et al. Early lung cancer detection: results of the initial (prevalence) radiologic and cytologic screening in the Mayo Clinic study. Am Rev Respir Dis. 1984;130:561–5.PubMedGoogle Scholar
  11. 11.
    Fontana RS, Sanderson DR, Woolner LB, et al. Screening for lung cancer: a critique of the Mayo Lung Project. Cancer. 1991;67:1155S–64S.CrossRefGoogle Scholar
  12. 12.
    Marcus PM, Bergstralh EJ, Fagerstrom RM, et al. Lung cancer mortality in the Mayo lung project: impact of extended follow-up. J Natl Cancer Inst. 2000;92:1308–16.PubMedCrossRefGoogle Scholar
  13. 13.
    Berlin N. Overview of the NCI cooperative early lung cancer detection program. Cancer. 2000;89:2349S–51S.CrossRefGoogle Scholar
  14. 14.
    Kubik A, Polak J. Lung cancer detection: results of a randomized prospective study in Czechoslovakia. Cancer. 1986;57:2427–37.PubMedCrossRefGoogle Scholar
  15. 15.
    Kubik AK, Parkin DM, Zatloukal P. Czech Study on Lung cancer screening: post-trial follow-up of lung cancer deaths up to year 15 since enrollment. Cancer. 2000;89:2363S–8S.CrossRefGoogle Scholar
  16. 16.
    Frost J, Ball WC, Levin M, et al. Early lung cancer detection: results of the initial (prevalence) radiologic and cytologic screening in the Johns Hopkins study. Am Rev Respir Dis. 1984;130:549–54.PubMedGoogle Scholar
  17. 17.
    Tockman MS. Survival and mortality from lung cancer in a screened population: the Johns Hopkins study. Chest. 1986;89:324S–5S.CrossRefGoogle Scholar
  18. 18.
    Melamed MR. Lung cancer screening results in the National Cancer Institute New York study. Cancer. 2000;89:2356S–62S.CrossRefGoogle Scholar
  19. 19.
    Bach PB, Silvestri GA, Hanger M, Jett JR. Screening for lung cancer: AACP evidence-based clinical practice guidelines (2nd ed.). Chest 2007;132:69S–77S. http://chestjournal.chestpubs.org/content/132/3_suppl/69S.long. Accessed 6 June 2011.
  20. 20.
    Henschke CI, Yankelevitz DF, Libby DM, et al. International early lung cancer action program investigators. survival of patients with stage I lung cancer detected on CT screening. N Engl J Med. 2006;355:1763–71.PubMedCrossRefGoogle Scholar
  21. 21.
    Bach PB, Jett JR, Pastorino U, et al. Computed tomography screening and lung cancer outcomes. JAMA. 2007;297:953–61.PubMedCrossRefGoogle Scholar
  22. 22.
    Swenson S, Aberle D, Kazerooni EA, et al. Consensus statement: CT screening for lung cancer. J Thorac Imaging. 2005;20:321.Google Scholar
  23. 23.
    National Cancer Institute. Lung cancer trial results show mortality benefit with low-dose CT: twenty percent fewer lung cancer deaths seen among those who were screened with low-dose spiral CT than with chest X-ray. http://www.cancer.gov/newscenter/pressreleases/2010/NLSTresultsRelease. Accessed 6 June 2011.
  24. 24.
    The National Lung Screening Trial Research Team. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med. 2011;365:395–409.CrossRefGoogle Scholar
  25. 25.
    White CS. National lung cancer screening trial: a breakthrough in lung cancer screening? J Thorac Imaging. 2011;26:86–7.PubMedCrossRefGoogle Scholar
  26. 26.
    Beasley MB, Brambilla E, Travis WD. The 2004 World Health Organization classification of lung tumors. SeminRoentgenol. 2005;40:90–7.Google Scholar
  27. 27.
    Kodama T, Shimosato Y, Koide T, et al. Endobronchial polypoid adenocarcinoma of the lung: histopathological and ultrastructural studies of five cases. Am J Surg Pathol. 1984;8:845–54.PubMedCrossRefGoogle Scholar
  28. 28.
    Travis WD, Brambilla E, Noguchi M, et al. International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. J Thoracic Oncol. 2011;6:244–85.CrossRefGoogle Scholar
  29. 29.
    Koss M, Travis W, Muran C, et al. Pseudomesotheliomatous adenocarcinoma: a reappraisal. Semin Diagn Pathol. 1992;9:117–23.PubMedGoogle Scholar
  30. 30.
    Kondo T, Yamada K, Noda K, et al. Radiologic-prognostic correlation in patients with small pulmonary adenocarcinomas. Lung Cancer. 2002;36:49–57.PubMedCrossRefGoogle Scholar
  31. 31.
    Takashima S, Maruyama Y, Hasegawa M, et al. CT findings in small peripheral adenocarcinoma of the lung: a retrospective study on 64 patients. Lung Cancer. 2002;36:289–95.PubMedCrossRefGoogle Scholar
  32. 32.
    Nagao M, Murase K, Yasuhara Y, et al. Measurement of localized ground glass attenuation on thin-section computed tomography: correlation with progression of bronchioloalveolar cell carcinoma of the lung. Invest Radiol. 2002;37:692–7.PubMedCrossRefGoogle Scholar
  33. 33.
    Colby T, Koss M, Travis WD. Tumors of the lower respiratory tract. 3rd ed. Washington: Armed Forces Institute of Pathology; 1995.Google Scholar
  34. 34.
    Soga J, Yakuwa Y. Bronchopulmonary carcinoids: an analysis of 1, 875 reported cases with special reference to a comparison between typical carcinoids and atypical varieties. Ann Thorac Cardiovasc Surg. 1999;5:211–9.PubMedGoogle Scholar
  35. 35.
    Union Internationale Contre le Cancer. TNM classification of malignant tumors. 7th ed. New York: Wiley-Blackwell; 2009.Google Scholar
  36. 36.
    Rami-Porta R, Crowley JJ, Goldstraw P. The revised TNM staging system for lung cancer. Ann Thorac Cardiovasc Surg. 2009;15:4–9.PubMedGoogle Scholar
  37. 37.
    Detterbeck FC, Boffa DJ, Tanoue LT. The new lung cancer staging system. Chest. 2009;136:260–71.PubMedCrossRefGoogle Scholar
  38. 38.
    Kligerman S, Abbott G. A radiologic review of the new TNM classification for lung cancer. Am J Roentgenol. 2010;194:562–73.CrossRefGoogle Scholar
  39. 39.
    Greaves SM, Brown K, Garon EB, Garon BL. The new staging system for lung cancer imaging and clinical implications. J Thorac Imaging. 2011;26:119–31.PubMedCrossRefGoogle Scholar
  40. 40.
    Suzuki C, Jacobsson H, Hatschek T, et al. Radiologic measurements of tumor response to treatment: practical approaches and limitations. Radiographics. 2008;329–344.Google Scholar
  41. 41.
    Gdeedo A, VanSchil P, Corthouts B, VanMieghem F, VanMeerbeeck J, VanMarck E. Comparison of imaging TNM [(i)TNM] and pathological TNM [pTNM] in staging of bronchogenic carcinoma. Eur J Cardiothorac Surg. 1997;12:224–7.PubMedCrossRefGoogle Scholar
  42. 42.
    Glazer H, Duncan-Meyer J, Aronberg D. Pleural and chest wall invasion in bronchogenic carcinoma: CT evaluation. Radiology. 1985;157:191–4.PubMedGoogle Scholar
  43. 43.
    Pennes D, Glazer G, Wimbish K, Gross B, Long R, Orringer M. Chest wall invasion by lung cancer: limitations of CT evaluation. Am J Roentgenol. 1985;144:507–11.Google Scholar
  44. 44.
    Ratto G, Piacenza G, Frola C. Chest wall involvement by lung cancer: computed tomographic detection and results of operation. Ann Thorac Surg. 1991;51:182–8.PubMedCrossRefGoogle Scholar
  45. 45.
    Venuta F, Rendina E, Ciriaco P. Computed tomography for preoperative assessment of T3 and T4 bronchogenic carcinoma. Eur J Cardiothorac Surg. 1992;6:238–41.PubMedCrossRefGoogle Scholar
  46. 46.
    Rendina E, Bognolo D, Mineo T. Computed tomography for the evaluation of intrathoracic invasion by lung cancer. J Thorac Cardiovasc Surg. 1987;94:57–63.PubMedGoogle Scholar
  47. 47.
    Pearlberg JL, Sandler MA, Beute GH, Lewis JW Jr, Madrazo BL. Limitations of CT in evaluation of neoplasms involving chest wall. J Comput Assist Tomogr. 1987;11:290–3.PubMedCrossRefGoogle Scholar
  48. 48.
    Gefter W. Magnetic resonance imaging in the evaluation of lung cancer. Semin RoentgenoI. 1990;25:73–84.CrossRefGoogle Scholar
  49. 49.
    Webb W, Sostman H. MR imaging of thoracic disease: clinical uses. Radiology. 1992;182:621–30.PubMedGoogle Scholar
  50. 50.
    Castagno A, Shuman W. MR imaging in clinically suspected brachial plexus tumor. Am J Roentgenol. 1987;149:1219–22.Google Scholar
  51. 51.
    Takasugi J, Rapoport S, Shaw C. Superior sulcus tumors: the role of imaging. J Thorac Imaging. 1989;4:41–8.PubMedCrossRefGoogle Scholar
  52. 52.
    Rapoport S, Blair D, McCarthy S, et al. Brachial plexus: correlation of MR imaging with CT and pathologic findings. Radiology. 1988;167:161–5.PubMedGoogle Scholar
  53. 53.
    Blair D, Rapoport S, Sostman H. Normal brachial plexus: MR imaging. Radiology. 1987;165:763–7.PubMedGoogle Scholar
  54. 54.
    Freundlich I, Chasen M, Dalla G. Magnetic resonance imaging of pulmonary apical tumors. J Thorac Imaging. 1996;11:210–22.PubMedGoogle Scholar
  55. 55.
    Martini N, Heelan R, Westcott J. Comparative merits of conventional, computed tomographic, and magnetic resonance imaging in assessing mediastinal involvement in surgically confirmed lung carcinoma. J Thorac Cardiovasc Surg. 1985;90:639–48.PubMedGoogle Scholar
  56. 56.
    Glazer H, Duncan-Meyer J, Aronberg D. Pleural and chest wall invasion in bronchogenic carcinoma: CT evaluation. Radiology. 1985;157:191–4.PubMedGoogle Scholar
  57. 57.
    De Wever W, Stroobants S, Coolen J, et al. Integrated PET/CT in the staging of nonsmall cell lung cancer: technical aspects and clinical integration. Eur Respir J. 2009;33:201–12.PubMedCrossRefGoogle Scholar
  58. 58.
    Rusch VW, Asamura H, Watanabe H, et al. The IASLC lung cancer staging project: a proposal for a new international lymph node map in the forthcoming seventh edition of the TNM classification for lung cancer. J Thorac Oncol. 2009;4:568–577.Google Scholar
  59. 59.
    Glazer G, Gross B, Quint L, et al. Normal mediastinal lymph nodes: number and size according to American thoracic society mapping. Am J Roentgenol. 1985;144:261–5.Google Scholar
  60. 60.
    Quint L, Glazer G, Orringer M, et al. Mediastinal lymph node detection and sizing at CT and autopsy. Am J Roentgenol. 1986;147:469–72.Google Scholar
  61. 61.
    Genereux G, Howie J. Normal mediastinal lymph node size and number: CT and anatomic study. Am J Roentgenol. 1984;142:1095–100.Google Scholar
  62. 62.
    Schnyder P, Gamsu G. CT of the pretracheal retrocaval space. Am J Roentgenol. 1981;136:303–8.Google Scholar
  63. 63.
    Kiyono K, Sone S, Sakai F. The number and size of normal mediastinal lymph nodes: a postmortem study. Am J Roentgenol. 1988;150:771–6.Google Scholar
  64. 64.
    Glazer G, Orringer M, Gross B, Quint L. The mediastinum in non-small cell lung cancer: CT-surgical correlation. Am J Roentgenol. 1984;142:1101–5.Google Scholar
  65. 65.
    Platt J, Glazer G, Gross B, Quint L, Francis I, Orringer M. CT evaluation of mediastinal lymph nodes in lung cancer: influence of the lobar site of the primary neoplasm. Am J Roentgenol. 1987;149:683–6.Google Scholar
  66. 66.
    Faling L, Pugatch R, Jung-Legg Y. Computed tomographic scanning of the mediastinum in the staging of bronchogenic carcinoma. Am Rev Respir Dis. 1981;124:690–5.PubMedGoogle Scholar
  67. 67.
    Baron R, Levitt R, Sagel S, et al. Computed tomography in the preoperative evaluation of bronchogenic carcinoma. Radiology. 1982;145:727–32.PubMedGoogle Scholar
  68. 68.
    Mouk G, Cockerill E, Farber M, et al. Computed tomography vs standard radiology in the evaluation of mediastinal adenopathy. Chest. 1982;82:69–75.CrossRefGoogle Scholar
  69. 69.
    Osborne D, Korobkin M, Ravin C. Comparison of plain radiography conventional tomography, and computed tomography in detecting intrathoracic lymph node metastases from lung carcinoma. Radiology. 1982;142:157–61.PubMedGoogle Scholar
  70. 70.
    Rea H, Shevland J, House A. Accuracy of computed tomographic scanning in assessment of the mediastinum in bronchial carcinoma. Thorac Cardiovasc Surg. 1981;81:825–9.Google Scholar
  71. 71.
    Buy J, Ghossain M, Poirson F. Computed tomography of mediastinal lymph nodes in nonsmall cell lung cancer. J Comput Assist Tomogr. 1988;12:545–52.PubMedCrossRefGoogle Scholar
  72. 72.
    Ikezoe J, Kadowaki K, Morimoto S. Mediastinal lymph node metastases from nonsmall cell bronchogenic carcinoma: reevaluation with CT. J Comput Assist Tomogr. 1990;14:340–4.PubMedCrossRefGoogle Scholar
  73. 73.
    Izbicki J, Thetter O, Karg O. Accuracy of computed tomographic scan and surgical assessment for staging of bronchial carcinoma. J Thorac Cardiovasc Surg. 1992;104:413–20.PubMedGoogle Scholar
  74. 74.
    Dales R, Stark R, Raman S. Computed tomography to stage lung cancer. Am Rev Respir Dis. 1990;144:1096–101.Google Scholar
  75. 75.
    Dwamena BA, Sonnad SS, Angobaldo JO, Wahl RL. Metastases from Non-small cell lung cancer: mediastinal staging in the 1990s—meta-analytic comparison of PET and CT. Radiology. 1999;213:530–6.PubMedGoogle Scholar
  76. 76.
    Erasmus JJ, McAdams HP, Patz EF. Non-small cell lung cancer: FDG-PET imaging. J Thorac Imaging. 1999;14:247–56.PubMedCrossRefGoogle Scholar
  77. 77.
    Pfister DG, Johnson DH, Azzoli CG. American society of clinical oncology treatment of unresectable non-small-cell Lung cancer guideline: update 2003. J ClinOncol. 2004; 22:330–353.Google Scholar
  78. 78.
    Lee BE, von Haag D, Lown T, et al. Advances in positron emission tomography technology have increased the need for surgical staging in non–small cell lung cancer. J Thorac Cardiovasc Surg. 2007;133:746–52.PubMedCrossRefGoogle Scholar
  79. 79.
    de Langen AJ, Raijmakers P, Riphagen I, et al. The size of mediastinal lymph nodes and its relation with metastatic involvement: a meta-analysis. Eur J Cardiothorac Surg. 2006;29:26–9.PubMedCrossRefGoogle Scholar
  80. 80.
    Antoch G, Stattaus J, Nemat AT, et al. Non-small cell lung cancer: dual-modality PET/CT in preoperative staging. Radiology. 2003;229:526–33.PubMedCrossRefGoogle Scholar
  81. 81.
    Quint LE, Tummala S, Brisson LJ, et al. Distribution of distant metastases from newly diagnosed non-small cell lung cancer. Ann Thorac Surg. 1996;62:246–50.PubMedCrossRefGoogle Scholar
  82. 82.
    Murayama S, Murakami J, Yoshimitsu K, et al. CT diagnosis of pleural dissemination without pleural effusion in primary lung cancer. Radiat Med. 1996;14:117–9.PubMedGoogle Scholar
  83. 83.
    Truong MT, Viswanathan C, Erasmus JJ. Positron emission tomography/computed tomography in lung cancer staging, prognosis, and assessment of therapeutic response. J Thorac Imaging. 2011;26:132–46.PubMedCrossRefGoogle Scholar
  84. 84.
    Dietlein M, Weber K, Gandjour A, et al. Cost-effectiveness of FDG-PET for the management of solitary pulmonary nodules: a decision analysis based on cost reimbursement in Germany. Eur J Nucl Med. 2000;27:1441–56.PubMedCrossRefGoogle Scholar
  85. 85.
    Valk PE, Pounds TR, Hopkins DM, et al. Staging non-small cell lung cancer by whole-body positron emission tomographic imaging. Ann Thorac Surg. 1995;60:1573–82.PubMedCrossRefGoogle Scholar

Copyright information

© Humana Press, a part of Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of RadiologyUniversity of South Florida College of MedicineTampaUSA
  2. 2.Department of Internal Medicine, Division of Pulmonary/Critical Care MedicineUSF College of MedicineTampaUSA
  3. 3.Moffitt Cancer CenterTampaUSA

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