Undertaking Regenerative Medicine Studies with Blood Stem Cells

Chapter
Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)

Abstract

In this chapter, we provide a perspective on the advances achieved to date in regenerative medicine, identify some of the challenges confronting the field, and make specific recommendations aimed at hastening the translation of research to effective clinical practice. Regenerative medicine is well positioned to address many of the urgent unmet medical needs of the global community. The stakes are high, but success will come only from the collaboration and mindfulness of specialists from diverse fields and from the focused attention of funding agencies.

Keywords

Single Photon Emission Compute Tomography Left Ventricular Ejection Fraction Human Leukocyte Antigen Regenerative Medicine Stem Cell Research 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgment

Armand Keating holds the Gloria and Seymour Epstein Chair in Cell Therapy and Transplantation at University Health Network and the University of Toronto.

References

  1. Bach FH, Albertini RJ, Joo P, Anderson JL, Bortin MM (1968) Bone-marrow transplantation in a patient with the Wiskott-Aldrich syndrome. Lancet 2:1364–1366PubMedCrossRefGoogle Scholar
  2. Bakondi B, Shimada IS, Perry A et al (2009) CD133 identifies a human bone marrow stem/progenitor cell sub-population with a repertoire of secreted factors that protect against stroke. Mol Ther 17:1938–1947PubMedCrossRefGoogle Scholar
  3. Ball LM, Bernardo ME, Roelofs H et al (2007) Cotransplantation of ex vivo expanded mesenchymal stem cells accelerates lymphocyte recovery and may reduce the risk of graft failure in haploidentical hematopoietic stem-cell transplantation. Blood 110:2764–2767PubMedCrossRefGoogle Scholar
  4. Barnes DW, Corp MJ, Loutit JF, Neal FE (1956) Treatment of murine leukaemia with X rays and homologous bone marrow; preliminary communication. Br Med J 2:626–627PubMedCrossRefGoogle Scholar
  5. Bortin MM (1970) A compendium of reported human bone marrow transplants. Transplantation 9:571–587PubMedCrossRefGoogle Scholar
  6. Brand JM, Meller B, Von Hof K et al (2004) Kinetics and organ distribution of allogeneic natural killer lymphocytes transfused into patients suffering from renal cell carcinoma. Stem Cells Dev 13:307–314PubMedCrossRefGoogle Scholar
  7. Chen SL, Fang WW, Ye F et al (2004) Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction. Am J Cardiol 94:92–95PubMedCrossRefGoogle Scholar
  8. Daar AS, Greenwood HL (2007) A proposed definition of regenerative medicine. J Tissue Eng Regen Med 1:179–184PubMedCrossRefGoogle Scholar
  9. Dausset J (1958) Iso-leuko-antibodies. Acta Haematol 20:156–166PubMedCrossRefGoogle Scholar
  10. de Vries IJ, Lesterhuis WJ, Barentsz JO et al (2005) Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy. Nat Biotechnol 23:1407–1413PubMedCrossRefGoogle Scholar
  11. Domansky K, Inman W, Serdy J, Dash A, Lim MH, Griffith LG (2010) Perfused multiwell plate for 3D liver tissue engineering. Lab Chip 10:51–58PubMedCrossRefGoogle Scholar
  12. Donndorf P, Kundt G, Kaminski A et al (2011) Intramyocardial bone marrow stem cell transplantation during coronary artery bypass surgery: a meta-analysis. J Thorac Cardiovasc SurgGoogle Scholar
  13. Frank JA, Miller BR, Arbab AS et al (2003) Clinically applicable labeling of mammalian and stem cells by combining superparamagnetic iron oxides and transfection agents. Radiology 228:480–487PubMedCrossRefGoogle Scholar
  14. Gatti RA, Meuwissen HJ, Allen HD, Hong R, Good RA (1968) Immunological reconstitution of sex-linked lymphopenic immunological deficiency. Lancet 2:1366–1369PubMedCrossRefGoogle Scholar
  15. Gnecchi M, Zhang Z, Ni A, Dzau VJ (2008) Paracrine mechanisms in adult stem cell signaling and therapy. Circ Res 103:1204–1219PubMedCrossRefGoogle Scholar
  16. Hanna J, Wernig M, Markoulaki S et al (2007) Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science 318:1920–1923PubMedCrossRefGoogle Scholar
  17. Haseltine WA (2001) The emergence of regenerative medicine: a new field and a new society. J Regen Med 2(4):17Google Scholar
  18. Henning TD, Wendland MF, Golovko D et al (2009) Relaxation effects of ferucarbotran-labeled mesenchymal stem cells at 1.5 T and 3 T: discrimination of viable from lysed cells. Magn Reson Med 62:325–332PubMedCrossRefGoogle Scholar
  19. Kang S, Yang YJ, Li CJ, Gao RL (2008) Effects of intracoronary autologous bone marrow cells on left ventricular function in acute myocardial infarction: a systematic review and meta-analysis for randomized controlled trials. Coron Artery Dis 19:327–335PubMedCrossRefGoogle Scholar
  20. Kebriaei P, Isola L, Bahceci E et al (2009) Adult human mesenchymal stem cells added to corticosteroid therapy for the treatment of acute graft-versus-host disease. Biol Blood Marrow Transplant 15:804–811PubMedCrossRefGoogle Scholar
  21. Koc ON, Gerson SL, Cooper BW et al (2000) Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy. J Clin Oncol 18:307–316PubMedGoogle Scholar
  22. Kruskall MS (1997) The perils of platelet transfusions. N Engl J Med 337:1914–1915PubMedCrossRefGoogle Scholar
  23. Lazarus HM, Koc ON, Devine SM et al (2005) Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients. Biol Blood Marrow Transplant 11:389–398PubMedCrossRefGoogle Scholar
  24. Le Blanc K, Samuelsson H, Gustafsson B et al (2007) Transplantation of mesenchymal stem cells to enhance engraftment of hematopoietic stem cells. Leukemia 21:1733–1738PubMedCrossRefGoogle Scholar
  25. Le Blanc K, Frassoni F, Ball L et al (2008) Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet 371:1579–1586PubMedCrossRefGoogle Scholar
  26. Ma Y, Xu Y, Xiao Z et al (2006) Reconstruction of chemically burned rat corneal surface by bone marrow-derived human mesenchymal stem cells. Stem Cells 24:315–321PubMedCrossRefGoogle Scholar
  27. Martin-Rendon E, Brunskill SJ, Hyde CJ, Stanworth SJ, Mathur A, Watt SM (2008) Autologous bone marrow stem cells to treat acute myocardial infarction: a systematic review. Eur Heart J 29:1807–1818PubMedCrossRefGoogle Scholar
  28. Meier R, Piert M, Piontek G et al (2008) Tracking of [18 F]FDG-labeled natural killer cells to HER2/neu-positive tumors. Nucl Med Biol 35:579–588PubMedCrossRefGoogle Scholar
  29. Meller B, Frohn C, Brand JM et al (2004) Monitoring of a new approach of immunotherapy with allogenic (111)In-labelled NK cells in patients with renal cell carcinoma. Eur J Nucl Med Mol Imaging 31:403–407PubMedCrossRefGoogle Scholar
  30. Milner CM, Day AJ (2003) TSG-6: a multifunctional protein associated with inflammation. J Cell Sci 116:1863–1873PubMedCrossRefGoogle Scholar
  31. Milner CM, Higman VA, Day AJ (2006) TSG-6: a pluripotent inflammatory mediator? Biochem Soc Trans 34:446–450PubMedCrossRefGoogle Scholar
  32. NIH Stem Cell Research Funding, FY 2002–2010 (2011) http://stemcells.nih.gov/research/funding/funding.htmGoogle Scholar
  33. Oh JY, Kim MK, Shin MS, Lee HJ, Lee JH, Wee WR (2008) The anti-inflammatory and anti-angiogenic role of mesenchymal stem cells in corneal wound healing following chemical injury. Stem Cells 26:1047–1055PubMedCrossRefGoogle Scholar
  34. Oh JY, Roddy GW, Choi H et al (2010) Anti-inflammatory protein TSG-6 reduces inflammatory damage to the cornea following chemical and mechanical injury. Proc Natl Acad Sci USA 107:16875–16880PubMedCrossRefGoogle Scholar
  35. Oude Munnink TH, Nagengast WB, Brouwers AH et al (2009) Molecular imaging of breast cancer. Breast 18(Suppl 3):S66–S73PubMedCrossRefGoogle Scholar
  36. Scacciatella P, Amato G, Ebrille E et al (2010) Current perspectives in cell therapy in cardiology: an overview of ongoing trials. G Ital Cardiol (Rome) 11:769–774Google Scholar
  37. Schachinger V, Erbs S, Elsasser A et al (2006) Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med 355:1210–1221PubMedCrossRefGoogle Scholar
  38. Singer NG, Caplan AI (2011) Mesenchymal stem cells: mechanisms of inflammation. Annu Rev Pathol 6:457–478PubMedCrossRefGoogle Scholar
  39. Storb R, Epstein RB, Bryant J, Ragde H, Thomas ED (1968) Marrow grafts by combined marrow and leukocyte infusions in unrelated dogs selected by histocompatibility typing. Transplantation 6:587–593PubMedCrossRefGoogle Scholar
  40. Storb R, Epstein RB, Graham TC, Thomas ED (1970) Methotrexate regimens for control of graft-versus-host disease in dogs with allogeneic marrow grafts. Transplantation 9:240–246PubMedCrossRefGoogle Scholar
  41. Storb R, Rudolph RH, Thomas ED (1971) Marrow grafts between canine siblings matched by serotyping and mixed leukocyte culture. J Clin Invest 50:1272–1275PubMedCrossRefGoogle Scholar
  42. Sutton EJ, Henning TD, Pichler BJ, Bremer C, Daldrup-Link HE (2008) Cell tracking with optical imaging. Eur Radiol 18:2021–2032PubMedCrossRefGoogle Scholar
  43. Takayama N, Nishimura S, Nakamura S et al (2010) Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells. J Exp Med 207:2817–2830PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Cell Therapy Program, Princess Margaret HospitalUniversity Health NetworkTorontoCanada
  2. 2.Division of Hematology, Department of MedicineUniversity of TorontoTorontoCanada

Personalised recommendations