Cellular-Based Therapies for Pediatric GI Motility Disorders

  • Ryo Hotta
  • Dipa Natarajan
  • Alan J. Burns
  • Nikhil Thapar
Part of the Clinical Gastroenterology book series (CG)


The therapeutic options for many gastrointestinal motility disorders remain inadequate and limited to palliative interventions. Recent advances in molecular biology and genetics have led to the identification of stem cells as potential tools for curative therapies. The field of neural stem cell therapies for enteric neuropathies has seen significant progress in recent years. A variety of sources for such neural stem cells have been identified ranging from embryonic stem cells to those derived from the CNS and, perhaps of most interest, from the gastrointestinal tract itself. The latter have been harvested from postnatal human gut even using minimally invasive techniques such as conventional endoscopy raising exciting possibilities for therapy including autologous therapy. A number of key challenges remain, however, before effective clinical application. These include better understanding of target diseases, the need to tailor cellular tools to optimize the treatment of individual diseases, and effective assessment of transplant success. Exciting developments including the identification of new stem cell sources such as induced pluripotent stem cells and improved access to donor tissue using less invasive techniques raise further hope for stem cells as effective therapies for enteric neuromuscular diseases.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Ryo Hotta
    • 1
    • 2
  • Dipa Natarajan
    • 3
  • Alan J. Burns
    • 3
  • Nikhil Thapar
    • 4
    • 5
  1. 1.Department of Anatomy and NeuroscienceThe University of MelbourneMelbourneAustralia
  2. 2.Department of Pediatric SurgeryKeio University School of MedicineTokyoJapan
  3. 3.Neural Development UnitUCL, Institute of Child HealthLondonUK
  4. 4.Gastroenterology Unit, Division of Neurogastroenterology and MotilityUniversity College London, Institute of Child HealthLondonUK
  5. 5.Department of Paediatric GastroenterologyGreat Ormond Street Hospital for ChildrenLondonUK

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