Gastroparesis pp 177-190 | Cite as

Diabetic Gastroparesis

  • Christopher K. RaynerEmail author
  • Karen L. Jones
  • Michael Horowitz
Part of the Clinical Gastroenterology book series (CG)


Gastric emptying is frequently disordered in patients with long-standing type 1 and type 2 diabetes mellitus. While patients with diabetes present with similar symptoms to those with idiopathic gastroparesis, the relationship between gastric emptying and glycemic control represents an important additional consideration in the diabetic group. Specifically, acute variations in the blood glucose concentration affect the rate of gastric emptying, while conversely, gastric emptying is a key determinant of postprandial blood glucose. This has implications both for how gastroparesis should be defined in patients with diabetes, and for its optimal management.


Diabetes mellitus Interstitial cells of Cajal Nitric oxide Heme ­oxygenase 1 Incretin Glucagon-like peptide 1 Insulin Blood glucose concentration 


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Christopher K. Rayner
    • 1
    • 2
    • 3
    Email author
  • Karen L. Jones
    • 4
  • Michael Horowitz
    • 4
  1. 1.Discipline of MedicineRoyal Adelaide Hospital, University of AdelaideAdelaideAustralia
  2. 2.Department of Gastroenterology and HepatologyRoyal Adelaide HospitalAdelaideAustralia
  3. 3.Centre of Clinical Research Excellence in Nutrition Physiology, Interventions, and OutcomesUniversity of AdelaideAdelaideAustralia
  4. 4.Discipline of MedicineUniversity of Adelaide, Royal Adelaide HospitalAdelaideAustralia

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