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Introduction to TRP Channels: Structure, Function, and Regulation

  • Michael Y. Song
  • Jason X.-J. YuanEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (volume 661)

Abstract

 Transient receptor potential or TRP families of ion channels demonstrate great diversity in activation and inhibition, and they are diverse in selectivity of ion conductance. TRP ion channels function as signal integrators through their ion conductance properties, and in some cases kinase activity. They mediate processes such as vision, taste, olfaction, hearing, touch, and thermo- and osmosensation. TRP cation channels function by mediating the flux of Na+ and Ca2+ across the plasma membrane and into the cytoplasm. The influx of cations into the cytoplasm depolarizes cells and is necessary for action potentials in excitable cells such as neurons. In non-excitable cells, membrane depolarization by TRP ) and-channels stimulates voltage- dependent channels (Ca2+, K+, Cl- influences many cellular events, such as transcription, translation, contraction, and migration. TRP channels are important in human physiology, and mutations in TRP genes are associated with at least four diseases. Furthermore, altered expression, function, and/or regulation of TRP channels have been implicated in diseases such as pulmonary hypertension.

Keywords

Canonical Vanilliod Melastatin Ankyrin Trpn=No mechanoreceptor potential Trpp=Polycystin Trpml=Mucolipin 

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Copyright information

© Humana Press, a part of Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.University of CaliforniaSan DiegoUSA

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