PPARγ and the Pathobiology of Pulmonary Arterial Hypertension
- Cite this paper as:
- Rabinovitch M. (2010) PPARγ and the Pathobiology of Pulmonary Arterial Hypertension. In: Yuan JJ., Ward J. (eds) Membrane Receptors, Channels and Transporters in Pulmonary Circulation. Advances in Experimental Medicine and Biology, vol 661. Humana Press, Totowa, NJ
Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor that functions as a transcription factor to regulate adipogenesis and metabolism by binding to PPAR response elements (PPAREs) in the promoter region of various target genes. Activation of PPARγ suppresses smooth muscle cell proliferation and migration. This chapter discusses the potential protective role of PPARγ and its downstream signaling cascades in the development of pulmonary arterial hypertension. Furthermore, the chapter also provides an overview on the cellular and molecular mechanisms involved in PPARγ-mediated inhibitory effect on pulmonary vascular remodeling, a major contributor to the elevated pulmonary vascular resistance in patients with pulmonary arterial hypertension.