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Therapeutic Targets and Drugs II: G-Quadruplex and G-Quadruplex Inhibitors

  • Chandanamali Punchihewa
  • Danzhou Yang
Chapter
Part of the Cancer Drug Discovery and Development book series (CDD&D)

Abstract

Human telomeric DNA consists of tandem repeats of the sequence d(TTAGGG) and can form G-quadruplex DNA secondary structures. Compounds that can stabilize the intramolecular DNA G-quadruplexes formed in the human telomeric sequence have been shown to inhibit the activity of telomerase and telomere maintenance, thus the telomeric DNA G-quadruplex has been considered as an attractive target for cancer therapeutic intervention. This review will give an overview of the current understanding of structures and biology of G-quadruplex secondary structures formed in human telomere, and of the current progress in the development of anticancer drugs targeting the telomeric G-quadruplexes.

Keywords

Human telomere G-quadruplex Anticancer drug target G-quadruplex ligands Telomeric G-quadruplex structure polymorphism 

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Copyright information

© Springer Science + Business Media, LLC 2009

Authors and Affiliations

  • Chandanamali Punchihewa
    • 1
  • Danzhou Yang
    • 1
  1. 1.College of PharmacyThe University of ArizonaTucsonUSA

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