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Factors Predisposing to Infection

  • Dean C. NormanEmail author
Chapter
Part of the Infectious Disease book series (ID)

Key Points

In the old, age-related changes in host defenses play a key role in the increased susceptibility and severity of infections.

Comorbidities are common in older persons and may further compromise host defenses.

Innate and adaptive immunity are now known to be interactive systems; both are affected by age and disease, and changes in innate immunity affects adaptive immunity.

Recent studies suggest that Toll-like receptors appear to be affected by age and that these changes may affect antigen presentation and optimal T-cell function.

Age-related changes in B-cell function and in B-cell and T-cell interaction result in diminished antigen-specific antibody production.

Keywords

Natural Killer Cell Host Defense Specific Immune Response Natural Killer Activity Mucosal Immune System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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Suggested Reading

  1. Gupta, S. (2005). Molecular mechanisms of apoptosis in the cells of the immune system in human aging. Immunology Review 205, 114–129.CrossRefGoogle Scholar
  2. Plackett, T.P., Boehmer, E.D., Faunce, D.E., & Kovacs, E. (2004). Aging and innate immune cells. Journal of Leukocyte Biology 76, 291–299.PubMedCrossRefGoogle Scholar
  3. van Duin, D., & Shaw, A.C. (2007). Toll-like receptors in older adults. Journal of American Geriatrics Society 55, 1438–1444.CrossRefGoogle Scholar

Copyright information

© Humana Press, a part of Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.VA Greater Los Angeles Healthcare System11301 Wilshire BoulevardUSA

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