Life Extension in the Short-Lived Fish Nothobranchius furzeri

Chapter
Part of the Aging Medicine book series (AGME)

Abstract

Genetic and pharmacological research on aging is hampered by the life span of available vertebrate models. We recently initiated studies on Nothobranchius furzeri, a species with a maximum life expectancy in captivity of just 3 months, the shortest documented captive life span for a vertebrate. Further research on N. furzeri has demonstrated the following:
  1. 1.

    Short life span correlates with explosive growth and accelerated sexual maturation.

     
  2. 2.

    Short life span is correlated with the expression of age-related behavioral and histological changes.

     
  3. 3.

    Life span and expression of age-related markers can be modulated by water temperature.

     
  4. 4.

    Resveratrol, a drug characterized by its life-extending action in Caenorhabditis elegans and Drosophila, increases life span and retards expression of age-related markers.

     
  5. 5.

    Aging-related genes can be easily isolated by homology cloning.

     
  6. 6.

    Different populations or species of Nothobranchius show large-scale differences in captive life span.

     

In the last 3 years, N. furzeri has moved from a biological curiosity to a promising model system for drug validation. Furthermore, this species occupies a favorable position in the phylogeny of teleosts. It is close to the Japanese medaka, the puffer fishes, and the sticklebacks, and may represent a useful model for the comparative genomics of aging.

Keywords

Nothobranchius furzeri resveratrol life span aging 

Abbreviations

BCT

Body core temperature

DR

Dietary restriction

GRZ

Gona Re Zhou

LF

Lipofuscin

SA-β-Gal

Senescence-associated β-galactosidase

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Copyright information

© Humana Press, a part of Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Fritz-Lipmann Institute for Age ResearchJenaGermany

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