Meige’s Syndrome

  • Roongroj Bhidayasiri
  • Daniel Tarsy
Part of the Current Clinical Neurology book series (CCNEU)


Meige syndrome refers to the combination of blepharospasm and orofacial dystonia. The term is mainly of historical interest having been described by Henry Meige in 1910 but described by others prior to that including the Flemish painter Pieter Bruegel the elder who portrayed affected individuals in several of his paintings. Marsden suggested that blepharospasm-oromandibular dystonia, like other adult-onset focal dystonias, is a partial expression of primary dystonia and currently is considered to be one of several forms of adult-onset focal dystonia. It is important to recognize that many patients who display blepharospasm with orofacial dyskinesia are manifesting semi-voluntary movements of their lower face in a struggle to keep their eyes open.


Botulinum Toxin Cervical Dystonia Botulinum Toxin Injection Facial Movement Focal Dystonia 
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Supplementary material

Meige Syndrome.mp4 (MP4 6,061KB)

The patient exhibits involuntary blepharospasm, lower facial grimacing, and anterocollis.


  1. 1.
    Meige H. Les convulsions de la face: une forme Clinique de convulsions facials, bilaterale et mediane. Rev Neurol (Paris). 1910;21:437–43.Google Scholar
  2. 2.
    Marsden C. David Blepharospasm-oromandibular dystonia syndrome (Bruegel’s syndrome): a variant of adult-onset torsion dystonia? J Neurol Neurosurg Psychiatry. 1976;59:1204–9.CrossRefGoogle Scholar
  3. 3.
    Tolosa ES, Klawans HL. Meige’s disease: a clinical form of facial convulsion, bilateral and medial. Arch Neurol. 1979;36:635–7.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Roongroj Bhidayasiri
    • 1
    • 2
  • Daniel Tarsy
    • 3
  1. 1.Chulalongkorn Center of Excellence on Parkinson’s Disease and Related DisordersChulalongkorn University HospitalBangkokThailand
  2. 2.Department of NeurologyDavid Geffen School of Medicine at UCLALos AngelesUSA
  3. 3.Department of NeurologyHarvard Medical School Beth Israel Deaconess Medical CenterBostonUSA

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