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Young-Onset Parkinson’s Disease

  • Roongroj Bhidayasiri
  • Daniel Tarsy
Chapter
Part of the Current Clinical Neurology book series (CCNEU)

Abstract

Young-onset Parkinson’s disease (YOPD) is arbitrarily defined as Parkinson’s disease which produces initial symptoms between ages 21 and 39. YOPD appears to be the same nosologic entity as older-onset Parkinson’s disease (PD). It accounts for approximately 5% of PD referrals in Western countries and about 10% in Japan. Compared with older-onset PD, the available evidence suggests that YOPD patients have (1) slower disease progression, (2) an increased frequency of dystonia at onset and during treatment, (3) a lower occurrence of dementia, and (4) an increased risk of dyskinesias in response to levodopa treatment. YOPD appears to form a heterogeneous patient group with a higher proportion of cases due to genetic causes.

Keywords

Initial Symptom Lower Occurrence Slit Lamp Examination Levodopa Treatment Slow Disease Progression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Supplementary material

Young-onset PD.mp4 (MP4 14,019KB)

Gait and turns are normal but left arm swing is reduced. There is facial masking. Left-sided rapid hand movements and finger tapping are markedly bradykinetic.

References

  1. 1.Golbe LI. Young-onset Parkinson’s disease: a clinical review. Neurology. 1991;41:168–73.PubMedCrossRefGoogle Scholar
  2. 2.Quinn N, Critchley P, Marsden CD. Young onset Parkinson’s disease. Mov Disord. 1987; 2:73–91.PubMedCrossRefGoogle Scholar
  3. 3.Wickremaratchi MM, Ben-Shlomo Y, Morris HR. The effect of onset age on the clinical features of Parkinson’s disease. Eur J Neurol. 2009;16:450–6.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Roongroj Bhidayasiri
    • 1
    • 2
  • Daniel Tarsy
    • 3
  1. 1.Chulalongkorn Center of Excellence on Parkinson’s Disease and Related DisordersChulalongkorn University HospitalBangkokThailand
  2. 2.Department of NeurologyDavid Geffen School of Medicine at UCLALos AngelesUSA
  3. 3.Department of NeurologyHarvard Medical School Beth Israel Deaconess Medical CenterBostonUSA

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