Young-Onset Parkinson’s Disease
Young-onset Parkinson’s disease (YOPD) is arbitrarily defined as Parkinson’s disease which produces initial symptoms between ages 21 and 39. YOPD appears to be the same nosologic entity as older-onset Parkinson’s disease (PD). It accounts for approximately 5% of PD referrals in Western countries and about 10% in Japan. Compared with older-onset PD, the available evidence suggests that YOPD patients have (1) slower disease progression, (2) an increased frequency of dystonia at onset and during treatment, (3) a lower occurrence of dementia, and (4) an increased risk of dyskinesias in response to levodopa treatment. YOPD appears to form a heterogeneous patient group with a higher proportion of cases due to genetic causes.
KeywordsInitial Symptom Lower Occurrence Slit Lamp Examination Levodopa Treatment Slow Disease Progression
Young-onset PD.mp4 (MP4 14,019KB)
Gait and turns are normal but left arm swing is reduced. There is facial masking. Left-sided rapid hand movements and finger tapping are markedly bradykinetic.