Young-Onset Parkinson’s Disease

  • Roongroj Bhidayasiri
  • Daniel Tarsy
Part of the Current Clinical Neurology book series (CCNEU)


Young-onset Parkinson’s disease (YOPD) is arbitrarily defined as Parkinson’s disease which produces initial symptoms between ages 21 and 39. YOPD appears to be the same nosologic entity as older-onset Parkinson’s disease (PD). It accounts for approximately 5% of PD referrals in Western countries and about 10% in Japan. Compared with older-onset PD, the available evidence suggests that YOPD patients have (1) slower disease progression, (2) an increased frequency of dystonia at onset and during treatment, (3) a lower occurrence of dementia, and (4) an increased risk of dyskinesias in response to levodopa treatment. YOPD appears to form a heterogeneous patient group with a higher proportion of cases due to genetic causes.


Initial Symptom Lower Occurrence Slit Lamp Examination Levodopa Treatment Slow Disease Progression 
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Supplementary material

Young-onset PD.mp4 (MP4 14,019KB)

Gait and turns are normal but left arm swing is reduced. There is facial masking. Left-sided rapid hand movements and finger tapping are markedly bradykinetic.


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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Roongroj Bhidayasiri
    • 1
    • 2
  • Daniel Tarsy
    • 3
  1. 1.Chulalongkorn Center of Excellence on Parkinson’s Disease and Related DisordersChulalongkorn University HospitalBangkokThailand
  2. 2.Department of NeurologyDavid Geffen School of Medicine at UCLALos AngelesUSA
  3. 3.Department of NeurologyHarvard Medical School Beth Israel Deaconess Medical CenterBostonUSA

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