Wilson’s Disease with Wing-Beating Tremor
The common neurologic manifestations of Wilson’s disease (WD) are dysarthria, tremor, dystonia, parkinsonism, and gait disturbance. While all tremor types may occur in WD, postural and resting tremors are the most common. The classical proximal “wing-beating” tremor of WD is often missing in the early stages of the disease. When it does appear, it is often resistant to decoppering therapy and antitremor drugs and results in severe disability. Recent MRI studies indicate that WD tremor is associated with lesions of the globus pallidus, the head of the caudate nucleus, and the substantia nigra. There is some experience indicating that uncontrolled bilateral upper limb tremor may respond to thalamotomy.
KeywordsPublic Health Internal Medicine Substantia Nigra Caudate Nucleus Severe Disability
Wilson’s Disease w. wing-beating tremor.mp4 ( MP4 2,328KB)
The patient exhibits bilateral “wing-beating” tremor associated with mild head tremor and cervical dystonia.