Targeted Cancer Therapy pp 271-287

Part of the Current Clinical Oncology™ book series (CCO)

Targeted Drug Therapy in Pancreatic Cancer

  • Don L. Gibbons
  • Robert A. Wolff
  • Gauri Varadhachary

Abstract

Only modest progress has been made in improving the overall survival of pancreatic cancer patients during the past 20 years with standard cytotoxic chemotherapy drugs. More work needs to be done to address the key biologic characteristics of pancreatic cancer that make it so aggressive, metastasizing at an early stage, and more refractory to standard treatments than most other solid tumor types. Here, we discuss the emerging role of targeted therapy in pancreatic cancer and the status of currently available and tested agents. We also point out the potential pitfalls in current trial designs and recommend new methods for testing novel compounds in this heterogeneous and difficult-to-treat group of patients.

Key Words

Targeted therapy Pancreatic cancer Chemotherapy Clinical trials 

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Copyright information

© Humana Press, Totowa, NJ 2008

Authors and Affiliations

  • Don L. Gibbons
  • Robert A. Wolff
  • Gauri Varadhachary

There are no affiliations available

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