Effect of Advanced Age on Male Infertility

  • Matthew Wosnitzer
  • Harry FischEmail author


Similar to females, males have biological clocks that affect the quality of their sperm, fertility levels, and hormone levels. Advanced paternal age increases the risk for occurrence of spontaneous abortion as well as genetic abnormalities in offspring due to multiple factors including DNA damage from abnormal apoptosis and reactive oxygen species. Increased paternal age is associated with a decrease in semen volume, percentage of normal sperm, and sperm motility. Males of advanced age must have a thorough physical examination with disclosure of sexual dysfunction and any medications that impair ejaculation or sperm formation. Men of advanced age should be counseled regarding the effects of paternal age on spermatogenesis and pregnancy. Future research will clarify novel treatments to increase fertility, reduce adverse genetic consequences, and increase the chance for a couple to have healthy children.


Male infertility Paternal age Spermato- genesis Male biological clock 


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Copyright information

© Humana Press, a part of Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Columbia University College of Physicians and Surgeons, Department of UrologyColumbia University Medical CenterNew YorkUSA

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