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Vitamin D pp 61-97 | Cite as

The Functional Metabolism and Molecular Biology of Vitamin D Action

  • Lori A. Plum
  • Hector F. DeLuca
Chapter
Part of the Nutrition and Health book series (NH)

Abstract

The evolution of our understanding of the biological impact of vitamin D is briefly reviewed, with a focus on the physiology and endocrinology of the vitamin D system. This chapter attempts to bring the molecular discoveries in vitamin D metabolism and mechanisms of action in to focus on known physiology and endocrinology. The latest developments on metabolism of vitamin D, the enzymes involved, and the genes responsible are presented. The impact of the molecular discoveries on current views of the importance of vitamin D in public health is also presented.

Key Words

Vitamin D vitamin D metabolism calcium intestine bone 25-hydroxyvitamin D 1,25-dihydroxyvitamin D vitamin D receptor calcium transport bone mobilization 

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Lori A. Plum
    • 1
  • Hector F. DeLuca
    • 1
  1. 1.Department of BiochemistryUniversity of Wisconsin-MadisonMadisonUSA

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