Eosinophilic Myositis

  • Albert Selva-O’ Callaghan
  • Josep M. Grau


Eosinophilic myositis (EM) constitutes a group of rare, clinically and pathologically heterogeneous disorders characterized by eosinophil infiltration of skeletal muscle. Parasitic infection is the commonest cause worldwide, but it can also be a feature of other conditions such as hypereosinophilic syndrome or muscle dystrophies. Most cases have no known etiological factor and are considered as idiopathic. EM should be distinguished from dermatomyositis and other systemic diseases such as Churg-Strauss granulomatosis. Idiopathic EM can be classified into three subtypes: focal EM, eosinophilic polymyositis, and eosinophilic perimyositis. Pathological studies are mandatory to differentiate and diagnose these entities.


Eosinophilic polymyositis perimyositis focal eosinophilic myositis 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Hall FC, Krausz T, and Walport MJ. (1995) Idiopathic eosinophilic myositis. QJ Med 88, 581–6.Google Scholar
  2. 2.
    Serratrice G, Pellisier JF, Roux H, and Quilichini P. (1990) Fasciitis, perimyositis, myositis, polymyositis and eosinophilia. Muscle Nerve 13, 385–95.CrossRefPubMedGoogle Scholar
  3. 3.
    Kaufman LD, Kephart GM, Seidman RJ, Buhmer D, Qvarfordt I, Nässberger L, et al. (1993) The spectrum of eosinophilic myositis. Clinical and immunopathogenic studies of three patients and review of the literature. Arthritis Rheum 36, 1014–24.CrossRefPubMedGoogle Scholar
  4. 4.
    Pickering MC, and Walport MJ. (1998) Eosinophilic myopathic syndromes. Curr Opin Rheumatol 10, 504–10.CrossRefPubMedGoogle Scholar
  5. 5.
    Bosch JA. (2001) Hypereosinophilic syndrome. Med Clin (Barc) 117, 375–6.Google Scholar
  6. 6.
    Wilkins HJ, Crane MM, Copeland K, and Williams WV. (2005) Hypereosinophilic syndrome: an update. Am J Haematol 80, 148–57.CrossRefGoogle Scholar
  7. 7.
    Kobayashi Y, Fujimoto T, Shiiki H, Kitaoka K, Murata K, and Dohi K. (2001) Focal eosinophilic myositis. Clin Rheumatol 20, 369–71.CrossRefPubMedGoogle Scholar
  8. 8.
    Hundt W, Stäbler A, and Reiser M. (1999) MRI findings of muscle involvement in idiopathic hypereosinophilic syndrome. Eur Radiol 9, 525–8.CrossRefPubMedGoogle Scholar
  9. 9.
    Dunand M, Lobrinus JA, Spertini O, and Kuntzer T. (2005) Eosinophilic perimyositis as the presenting feature of a monoclonal T-cell expansion. Muscle Nerve 31, 646–51.CrossRefPubMedGoogle Scholar
  10. 10.
    Watts RA. (2001) Eosinophilia and musculoskeletal disease. Curr Opin Rheumatol 13, 57–61.CrossRefPubMedGoogle Scholar
  11. 11.
    Krahn M, Lopez de Munain A, Streichenberg N, Bernard R, Pécheux C, Testard H, et al. (2006) CAPN3 Mutations in patients with idiopathic eosinophilic myositis. Ann Neurol 59, 905–11.CrossRefPubMedGoogle Scholar
  12. 12.
    Brown RH, and Amato A. (2006) Calpainopathy and eosinophilic myositis. Ann Neurol 59, 875–7.CrossRefPubMedGoogle Scholar
  13. 13.
    Murata K, Sugie K, Takamure M, Fujimoto T, and Ueno S. (2003) Eosinophilic major basic protein and interleukin-5 in eosinophilia myositis. Eur J Neurol 10, 35–38.CrossRefPubMedGoogle Scholar
  14. 14.
    Ishizawa K, Adachi D, Kuboi K, Yamaguchi T, Mitsuhashi T, Shimizu Y,. (2006) Multiple organ involvement in eosinophilic polymyositis: an autopsy report. Hum Pathol 37, 231–5.CrossRefPubMedGoogle Scholar

Copyright information

© Humana Press, a part of Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Albert Selva-O’ Callaghan
    • 1
  • Josep M. Grau
    • 2
  1. 1.Internal Medicine Department, Hospital Vall d’HebrónUniversitat Autónoma de BarcelonaBarcelonaSpain
  2. 2.Department of Internal Medicine, Muscular Research Group, Hospital ClínicUniversity of BarcelonaBarcelonaSpain

Personalised recommendations