Drug-Induced Autoimmunity

  • Martine Szyper-Kravitz
  • Yehuda Shoenfeld

Abstract

Drug-induced autoimmunity encompasses a wide range of serological and clinical manifestations that develop after exposure to a drug. The classical and most studied example is drug-induced lupus (DIL). Although autoimmunity secondary to drugs has been recognized for more than 50 years, the introduction of new drugs has extended the spectrum and severity of clinical manifestations. Several drugs are associated with the induction of antinuclear and anti-DNA antibodies, but clinical lupus is rare, and a number of drugs are associated with antineutrophilic cytoplasmic antibody (ANCA)-positive vasculitis. The diagnosis of these conditions is not simple and requires careful elimination of other possible conditions. Although rare cases of life-threatening autoimmune conditions have been described, the majority of cases are mild and resolve after the offending drug is discontinued.

Keywords

Drug-induced idiosyncratic reactions drug-induced lupus 

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Copyright information

© Humana Press, a part of Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Martine Szyper-Kravitz
    • 1
  • Yehuda Shoenfeld
    • 2
    • 3
  1. 1.Center for Autoimmune Diseases and, Department of Medicine B, Chaim Sheba Medical Center Tel-Hashomer, Sackler Faculty of MedicineTel Aviv UniversityIsrael
  2. 2.Department of Medicine B, Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, And Sackler Faculty of MedicineTel Aviv UniversityIsrael
  3. 3.Incumbent of the Laura Schwartz Kipp Chair, for Research of Autoimmune DiseasesTel Aviv UniversityIsrael

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