Epidemiology of Type 2 Diabetes Mellitus in Pediatric Populations

  • Shreepal M. Shah
Part of the Nutrition and Health book series (NH)

Key Points

T2DM is directly related to obesity across the life span. Pediatric obesity and T2DM remain increasingly epidemic worldwide.


Pediatric Obesity Type 2 diabetes mellitus Epidemic 


  1. 1.
    King H, Aubert RE, Herman WH (1998) Global burden of diabetes, 1995–2025. Diab Care 21:1414–1431CrossRefGoogle Scholar
  2. 2.
    American Diabetes Association (2008) Economic costs of diabetes in the US in 2007. Diab Care 31:596–615CrossRefGoogle Scholar
  3. 3.
    Anonymous (2000) Type 2 diabetes in children and adolescents. American Diabetes Association. Diabetes Care 323:381–390Google Scholar
  4. 4.
    Savage PJ, Bennett PH, Senter RG, Miller M (1979) High prevalence of diabetes in young Pima Indians. Diabetes 28:937–942PubMedCrossRefGoogle Scholar
  5. 5.
    Dean HE, Mundy RL, Moffatt M (1992) Non-insulin-dependent diabetes mellitus in Indian children in Manitoba. Can Med Assoc J 147:52–57Google Scholar
  6. 6.
    Dean H (1998) NIDDM-Y in First Nation children in Canada. Clin Pediatr 39:89–96CrossRefGoogle Scholar
  7. 7.
    Harris SB, Perkins BA, Whalen-Brough E (1996) Non-insulin dependent diabetes ­mellitus among First Nations children: new entity among First Nations people of Northwestern Ontario. Can Fam Physician 42:869–876PubMedGoogle Scholar
  8. 8.
    Pinhas-Hamiel O, Dolan LM, Daniels SR, Standiford D, Khoury PR, Zeitler P (1996) Increased incidence of non-insulin-dependent diabetes mellitus among adolescents. J Pediatr 128:608–615PubMedCrossRefGoogle Scholar
  9. 9.
    Scott CR, Smith JM, Cradock M, Pihoker C (1997) Characteristics of youth-onset non-insulin-dependent diabetes mellitus and insulin dependent diabetes mellitus at diagnosis. Pediatrics 100:84–91PubMedCrossRefGoogle Scholar
  10. 10.
    Pihoker C, Scott CR, Lensing SY, Cradock MM, Smith J (1998) Non-insulin dependent diabetes mellitus in African American youths of Arkansas. Clin Pediatr 37:97–102CrossRefGoogle Scholar
  11. 11.
    Harwell TS, McDowall JM, Moore K, Fagot-Campagna A, Helgerson SD, Gohdes D (2001) Establishing surveillance for diabetes in African Indian youths. Diab Care 24:1029–1032CrossRefGoogle Scholar
  12. 12.
    Moore KR, Harwell TS, McDowall JM, Helgerson SD, Gohdes D (2003) Three-year prevalence and incidence of diabetes among American Indian youth in Montana and Wyoming, 1999 to 2001. J Pediatr 143:368–371PubMedCrossRefGoogle Scholar
  13. 13.
    Kim C, McHugh C, Kwok Y, Smith A (1999) Type 2 diabetes mellitus in Navajo adolescents. West J Med 170:210PubMedGoogle Scholar
  14. 14.
    Oeltmenn JE, Liese AD, Heinze HJ, Addy CL, Mayer-Davis EJ (2003) Prevalence of diagnosed diabetes among African–American and non-Hispanic white youth. Diab Care 26:2531–2535CrossRefGoogle Scholar
  15. 15.
    Grinstein G, Muzmudar R, Aponte L, Vuguin P, Saenger P, DiMartino-Nardi J (2003) Presentation and 5-year follow-up of type 2 diabetes mellitus in African-American and Caribben-Hispanic adolescents. Horm Res 60:121–126PubMedCrossRefGoogle Scholar
  16. 16.
    Writing Group for the SEARCH for Diabetes in Youth Study Group, Dabelea D, Bell RA, D’Agostino RB Jr, Imperatore G, Johansen JM, Linder B, Liu LL, Loots B, Marcovina S, Mayer-Davis EJ, Pettitt DJ, Waitzfelder B (2007) Incidence of diabetes in youth in the United States. JAMA 297:2716–2724PubMedCrossRefGoogle Scholar
  17. 17.
    National Diabetes Statistics (2007) Accessed 26 February 2010
  18. 18.
    Brooks-Worrell BM, Greenaum CJ, Palmer JP, Pihoker C (2004) Autoimmunity to islets proteins in children diagnosed with new-onset diabetes. J Clin Endocinol Metab 89:2222–2227CrossRefGoogle Scholar
  19. 19.
    Hathout EH, Thomas W, EI Shahawy M, Nahab F, Mace JW (2001) Diabetic autoimmune markers in children and adolescents with type 2 diabetes. Pediatrics 107:E102PubMedCrossRefGoogle Scholar
  20. 20.
    Kadiki OA, Reddy MR, Marzouk AA (1996) Incidence of insulin-dependent diabetes (IDDM) and non-insulin-dependent diabetes (NIDDM) (0-34 years at onset) in Benghazi, Libya. Diabetes Res Clin Pract 32:165–173PubMedCrossRefGoogle Scholar
  21. 21.
    Kitagawa T, Owada M, Urakami T, Tajima N (1994) Epidemiology of type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus in Japanese children. Diabetes Res Clin Pract 24(Suppl):S7–S13Google Scholar
  22. 22.
    Kitagawa T, Owada M, Urakami T, Yamauchi K (1998) Increased incidence of non-dependent diabetes mellitus among Japanese school children correlates with an increased intake of animal protein and fat. Clin Pediatr 37:111–115CrossRefGoogle Scholar
  23. 23.
    Invitti C, Guzzaloni G, Giraldinini L (2003) Prevalence and concomitants of glucose intolerance in European obese children and adolescents. Diab Care 26:118–124CrossRefGoogle Scholar
  24. 24.
    Wabitsch M, Hauner H, Hertrampf M, Muche R, Hay B, Mayer H, Kratzer W, Debatin KM, Heinze E (2004) Type II diabetes mellitus and impaired glucose regulation in Caucasian children and adolescents with obesity living in Germany. Int J Obes Relat Metab Disord 28:307–313PubMedGoogle Scholar
  25. 25.
    Grabert M, Krause U, Rami B, Scober E, Schweiggert F, Thon A (2003) Prevalence and clinical characteristics of patients with non-type -1-diabetes in pediatric age range: analysis of multicenter database including 20 401 patients from 148 centers in Germany and Austria (Abstract). Diabetologia 46(Suppl 2):26Google Scholar
  26. 26.
    Zachrisson I, Tibell C, Bang P, Ortquist E (2003) Prevalence of type 2 diabetes among known cases of diabetes aged 0-18 years in Sweden (Abstract). Diabetologia 46(Suppl 2):56Google Scholar
  27. 27.
    Nicklas TA (2001) Eating patterns, dietary quality and obesity. J Am Coll Nutr 20:599–608PubMedGoogle Scholar
  28. 28.
    Parsons TJ, Power C, Logan S, Summerbell CD (1999) Childhood predictors of adult obesity: a systemic review. Int J Obes Relat Metab Disord 23:S1–S107PubMedGoogle Scholar
  29. 29.
    Whitaker RC, Wright JA, Pepe MS, Seidel KD, Dietz WH (1997) Predicting obesity in young adulthood from childhood and parental obesity. N Engl J Med 337:869–874PubMedCrossRefGoogle Scholar
  30. 30.
    Strauss RS, Pollock HA (2001) Epidemic increase in childhood overweight, 1986–1998. JAMA 286:2845–2848PubMedCrossRefGoogle Scholar
  31. 31.
    James PT (2004) Obesity: the worldwide epidemic. Clin Dermatol 22:276–280PubMedCrossRefGoogle Scholar
  32. 32.
    Pi-Sunyer FX (1993) Medical hazards of obesity. Ann Intern Med 119:655–660PubMedGoogle Scholar
  33. 33.
    Ogden CL, Flegal KM, Johnson CL (2002) Prevalence and trends in overweight among U.S. children and adolescents, 1999–2000. JAMA 288:1728–1732PubMedCrossRefGoogle Scholar
  34. 34.
    Hedley AA, Ogden CL, Johnson CL, Carroll MD, Curtin LR, Flegal KM (2004) Prevalence of overweight and obesity among us children, adolescence and adults, 1999–2002. JAMA 291:2847–2850PubMedCrossRefGoogle Scholar
  35. 35.
    Ogden CL, Carroll MD, Flegal KM (2008) High body mass index for age among US children and adolescents, 2003–2006. JAMA 299:2401–2405PubMedCrossRefGoogle Scholar
  36. 36.
    NHANES Surveys (1976–1980 and 2003–2006). Accessed 4 March 2010
  37. 37.
    American Diabetes Association (2000) Type 2 diabetes in children and adolescents. Diab Care 23:381–389CrossRefGoogle Scholar
  38. 38.
    Sorof JM, Lai D, Turner J, Poffenbarger T, Portman RJ (2004) Overweight, ethnicity and the prevalence of hypertension in school-aged children. Pediatrics 113:475–482PubMedCrossRefGoogle Scholar
  39. 39.
    Freedman DS, Khan LK, Dietz WH, Srinivasan SR, Berenson GS (2001) Relationship of childhood obesity to coronary heart disease risk factors in adulthood: the Bogalusa heart Study. Pediatrics 108:712–718PubMedCrossRefGoogle Scholar
  40. 40.
    Becque MD, Katch VL, Rocchini AP, Marks CR, Moorehead C (1988) Coronary risk incidence of obese adolescents: reduction by exercise plus diet intervention. Pediatrics 81:605–612PubMedGoogle Scholar
  41. 41.
    Ranjana S, Gene F, Barbara T, William VT, Bruna B, Karin A, Mary S, Vera R, Sara T, Gina B, Robert S, Sonia C (2002) Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. N Engl J Med 346:802–810CrossRefGoogle Scholar
  42. 42.
    Cruz ML, Bergman RN, Goran MI (2002) Unique effect of visceral fat on insulin sensitivity in obese Hispanic children with a family history of type 2 diabetes. Diab Care 25:1631–1636CrossRefGoogle Scholar
  43. 43.
    Fagot-Campagna A (2000) Emergence of type 2 diabetes mellitus in children: epidemiological evidence. J Pediatr Endocrinol Metab 13:11395–11402Google Scholar
  44. 44.
    Haslam DW, James WP (2005) Obesity. Lancet 366:1197–1209PubMedCrossRefGoogle Scholar
  45. 45.
    Wild S, Roglic G, Green A, Sicree R, King H (2004) Global prevalence of diabetes: estimates for the year 2000 and the projections for 2030. Diab Care 27:1047–1053CrossRefGoogle Scholar
  46. 46.
    Wei JN, Sung FC, Lin CC, Lin RS, Chiang CC, Chuang LM (2003) National surveillance for type 2 diabetes mellitus in Taiwanese children. JAMA 290:1345–1350PubMedCrossRefGoogle Scholar
  47. 47.
    Lee WR (2000) The changing demography of diabetes mellitus in Singapore. Diabetes Res Clin Pract 50:S35–S39PubMedCrossRefGoogle Scholar
  48. 48.
    Likitmaskul S, Tuchinda C, Punnakanta L, Kiattisakthavee P, Chaichanwattanakul K, Angsusingha K (2000) Increase of type 2 diabetes in Thai children and adolescents in Thailand. J Pediatr Endocrinol Metab 13:1209Google Scholar
  49. 49.
    Likitmaskul S, Kiattisathavee P, Chaichanwatanakul K, Punnakanta L, Angsusingha K, Tuchindra C (2003) Increasing prevalence of type 2 diabetes mellitus in Thai children and adolescents associated with increasing prevalence of obesity. J Pediatr Endocrinol Metab 16:71–77PubMedCrossRefGoogle Scholar
  50. 50.
    Likitmaskul S, Kiattisathavee P, Chaichanwatanakul K, Punnakanta L, Angsusingha K, Tuchindra C (2000) Epidemiology of diabetes mellitus in children in Hong Kong: the Hong Kong childhood diabetes registry. J Pediatr Endocrinol Metab 13:297–302CrossRefGoogle Scholar
  51. 51.
    Zhi D, Shen S, Luo F, Zhao Z, Hong Q (2003) IDF WPR childhood and adolescence, Diabcare survey 2001 in Shanghai (Abstract). O-25, ISPAD, Saint-MaloGoogle Scholar
  52. 52.
    Narayan KM, Fagot-Campagna A, Imperatore G (2001) Type 2 diabetes in children: a problem lurking for India? Indian Pediatr 38:701–704PubMedGoogle Scholar
  53. 53.
    Hotu S, Carter B, Watson PD, Cutfield WS, Cundy T (2004) Increasing prevalence of type 2 diabetes in adolescents. J Paediatr Child Health 40:201–204PubMedCrossRefGoogle Scholar
  54. 54.
    Schober E, Rami B, Nachbauer E, Waldhor T, and the Australian Diabetes Incidence Study Group (2002) Type 2 diabetes is rare but not absent in children <15 years in Austria (Abstract). The 9th European workshop on pediatric endocrinology, SlovakiaGoogle Scholar
  55. 55.
    Rami B, Schober E, Nachbauer E, Waldhor T (2003) Austrian Diabetes Incidence Study group. Type 2 diabetes mellitus is rare but not absent in children under 15 years of age in Austria. Eur J Pediatr 162:850–852PubMedCrossRefGoogle Scholar
  56. 56.
    Ehtisham S, Kirk J, McEvilly A, Shaw N, Jones S, Rose S (2001) Prevalence of type 2 diabetes in children in Birminghham. BMJ 322:1428PubMedCrossRefGoogle Scholar
  57. 57.
    Ortega-Rodriguez E, Levy-Marchal C, Tubiana N, Czernichow P, Polak M (2001) Emergence of type 2 diabetes in a hospital based cohort of children with diabetes mellitus. Diabetes Metab 27:574–578PubMedGoogle Scholar
  58. 58.
    Zachrisson I, Tibell C, Bang P, Ortqvist E (2003) Prevalence of type 2 diabetes among known cases of diabetes aged 0-18 in Sweden (Abstract). 18th International Diabetes Federation Congress, Paris, FranceGoogle Scholar
  59. 59.
    Davis E (2002) Incresing type 2 diabetes in children and adolescents in Western Australia (Abstract). Australian Diabetes Society and Australian Diabetes Educators Association. p 336Google Scholar
  60. 60.
    Harkin N (2002) Increasing recognisation of Type 2 diabetes in adolescents (Abstract). Australian Diabetes Society and Australian Diabetes Educators Association, p 171Google Scholar
  61. 61.
    El-Hazmi MAF, Warsy AS, AL-Swailem AR, Al-Swailem AM, Sulaimani R (1998) Diabetes mellitus as a health problem in Saudi Arabia and its complications. Eastern Mediterr Health J 4:58–67Google Scholar
  62. 62.
    Punnose J (2002) Childhood and adolescent diabetes mellitus in Arabs residing in the United Arab Emirates. Diabetes Res Clin Pract 55:29–33PubMedCrossRefGoogle Scholar
  63. 63.
    Ramos O, Ferraro M, Andres ME, Arce L (2003) Type 2 diabetes in youth, an increasing problem in Buenos Aires? (Abstract). 18th International Diabetes Federation Congress, Paris, FranceGoogle Scholar
  64. 64.
    Freedman DS, Shrinivasan SR, Valdez RA, Williamson DF, Berenson GS (1997) Secular increase in relative weight and adiposity among children over two decades: the Bogulusa Heart Study. Pediatrics 99:420–426PubMedCrossRefGoogle Scholar
  65. 65.
    Zametkin AJ, Zoon CK, Klein HW, Munson S (2004) Psychiatric aspects of child and adolescent obesity: a review of the past 10 years. J Am Acad Child Adolesc Psychiatry 43:134–150PubMedCrossRefGoogle Scholar
  66. 66.
    Kotani K, Nishida M, Yamashita S, Funahashi T, Fujioka S, Tokunaga K, Ishikawa K, Tarui S, Matsuzawa Y (1997) Two decades of annual medical examination in Japanese obese children: do obese children grow into obese adults? Int J Obes Relat Metab Disord 27:912–921CrossRefGoogle Scholar
  67. 67.
    Lobstein TJ, James WP, Cole TJ (2003) Increasing levels of excess weight among children in England. Int J Obes Relat Metab Disord 27:1136–1138PubMedCrossRefGoogle Scholar
  68. 68.
    Moreno LA, Sarria A, Popkin BM (2002) The nutrition transition in Spain: a European Mediterranean country. Eur J Clin Nutr 56:992–1003PubMedCrossRefGoogle Scholar
  69. 69.
    Rolland-Cachera MF, Deheeger M, Thibault H (2001) Epidemological basis of obesity. Arch Pediatr 8(Suppl 2):287–289CrossRefGoogle Scholar
  70. 70.
    Krassas GE, Tzotzas T, Tsametis C, Konstantinidis T (2005) Prevalence and trends in overweight and obesity among children and adolescents in Thessaloniki, Greece. J Pediatr Endocrinol Metab 14:1319–1365Google Scholar
  71. 71.
    Macaluso CJ, Bauer UE, Deeb LC, Malone JI, Chaudhari M, Silverstein J et al. (2002) Type 2 diabetes mellitus among Florida children and adolescents, 1994 through 1998. Public Health Rep 117:373–379PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Shreepal M. Shah
    • 1
  1. 1.Division of Pediatric Endocrinology, Department of PediatricsThe University of Tennessee Health Science Center at MemphisMemphisUSA

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