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Atypical Parkinsonism in the French West Indies: The Plant Toxin Annonacin as a Potential Etiological Factor

  • Annie Lannuzel
  • Patrick Pierre Michel
Chapter
Part of the Contemporary Neuroscience book series (CNEURO)

This chapter describes the phenotypic and clinical features of an atypical parkinsonian syndrome endemic to the Caribbean island of Guadeloupe. The clinical entity was much more frequent than idiopathic Parkinson’s disease. It corresponded to a unique combination of levodopa-resistant parkinsonism, tremor, myoclonus, hallucinations, REM sleep behavior disorder and fronto-subcortical dementia. Epidemiological and experimental studies suggested that the neurological syndrome resulted from chronic intoxication by a mitochondrial complex I inhibitor, the plant toxin annonacin.

Keywords

Progressive Supranuclear Palsy Progressive Supranuclear Palsy Atypical Parkinsonism Progressive Supranuclear Palsy Patient Atypical Parkinsonian Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Humana Press, a part of Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.INSERM, UMR_S 975, Neurology and Experimental TherapeuticsF-75013 ParisFrance
  2. 2.UPMC Univ Paris 06, UMR_S 975F-75005 ParisFrance
  3. 3.Department of NeurologyCentre Hospitalier UniversitaireF-97159 Pointe-à-Pitre

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