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MicroRNAs and Discovery of New Targets

  • Soken Tsuchiya
  • Yasushi Okuno
  • Gozoh Tsujimoto
Part of the Cancer Drug Discovery and Development™ book series (CDD&D)

Summary

MicroRNAs are endogenous short non-coding RNAs that regulate gene expression mainly at the post-transcriptional level by base pairing to the 3′ untranslated region of target messenger RNAs. At present, hundreds of microRNAs have been identified in humans, and some of them have been revealed to play a critical role especially in the initiation, progression, and malignant potential of various cancers. In this chapter, we discuss the role of microRNAs in cancer and its potential application for cancer therapy.

Key Words

MicroRNA non-coding RNA translational suppression cancer oncogene tumor suppressor gene diagnosis antisense oligonucleotide drug discovery 

Notes

Acknowledgements

We would like to thank Dr. N. Hirota for her invaluable advice. We apologize for the incompleteness of the referencing due to space limitations and timing.

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Copyright information

© Humana Press, a part of Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Soken Tsuchiya
    • 1
  • Yasushi Okuno
    • 2
  • Gozoh Tsujimoto
    • 3
  1. 1.Department of Genomic Drug Discovery Science, Department of PharmacoInformaticsGraduate School of Pharmaceutical Sciences, Kyoto UniversityKyotoJapan
  2. 2.Department of PharmacoInformaticsGraduate School of Pharmaceutical Sciences, Kyoto UniversityKyotoJapan
  3. 3.Department of Genomic Drug Discovery ScienceGraduate School of Pharmaceutical Sciences, Kyoto UniversityKyotoJapan

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