Statins for Treatment of Pulmonary Hypertension

  • John L. Faul
  • Peter N. Kao
  • Toshihiko Nishimura
  • Arthur Sung
  • Hong Hu
  • Ronald G. Pearl
Part of the Contemporary Cardiology™ book series (CONCARD)

Abstract

By virtue of their multiple actions, including anti-inflammatory, antiproliferative, and pro-apoptotic traits and the ability to restore endothelial vasoactive mediator production, statins have been proposed as potential therapies for pulmonary hypertension. In experimental studies in rats with pulmonary hypertension induced either by either monocrotaline or hypoxia, statins have blunted the severity of pulmonary hypertension, right ventricular hypertrophy, and pulmonary vascular remodeling, sometimes in association with the restoration of the endothelial cell production of nitric oxide. Pending trials that demonstrate the efficacy of statins in pulmonary arterial hypertension in humans, however, the clinical use of statins should be considered investigational.

Keywords

statins pulmonary hypertension therapy monocrotaline chronic hypoxia experimental pulmonary hypertension simvastatin 

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Copyright information

© Humana Press, Totowa, NJ 2008

Authors and Affiliations

  • John L. Faul
  • Peter N. Kao
  • Toshihiko Nishimura
  • Arthur Sung
  • Hong Hu
  • Ronald G. Pearl

There are no affiliations available

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